Universität zu Köln

Schneider, Christian, Sprenger, Alina, Weiss, Kilian ORCID: 0000-0003-4295-4585, Slebocki, Karin, Maintz, David, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Henning, Tobias D., Lehmann, Helmar C. and Lichtenstein, Thorsten (2019). MRI detects peripheral nerve and adjacent muscle pathology in non-systemic vasculitic neuropathy (NSVN). J. Neurol., 266 (4). S. 975 - 982. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1432-1459

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Abstract

BackgroundDiagnosis and disease monitoring of non-systemic vasculitic neuropathy (NSVN) are based on electrophysiological and clinical measures. However, these methods are insensitive to detect subtle differences of axonal injury. We here assessed the utility of a multiparametric MRI protocol to quantify axonal injury and neurogenic muscle damage in NSVN.MethodsTen NSVN patients and ten age-matched controls were investigated in this single-center prospective study. All participants were assessed by diffusion tensor imaging (DTI) of the tibial nerve and multiecho Dixon MRI of soleus and gastrocnemius muscles. These data were correlated with clinical and electrophysiological data.ResultsDTI scans of the tibial nerves of patients with NSVN showed significantly lower mean fractional anisotropy (FA) values (0.320.02) compared to healthy controls (0.42 +/- 0.01). FA values of NSVN patients correlated negatively with clinical measures of pain. Multiecho Dixon MRI scans revealed significantly higher intramuscular fat fractions in the soleus muscle (19.86 +/- 6.18% vs. 5.86 +/- 0.74%, p=0.0015) and gastrocnemius muscle (26.09 +/- 6.21% vs. 3.59 +/- 0.82%, p=0.0002) in NSVN patients compared to healthy controls.Conclusion p id=Par4 Our data provide a proof of concept that MRI can render information about nerve integrity and muscle pathology in NSVN. Further studies are warranted to evaluate DTI and multiecho Dixon MRI as surrogate markers in NSVN.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schneider, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Sprenger, Alina UNSPECIFIED UNSPECIFIED UNSPECIFIED Weiss, Kilian UNSPECIFIED orcid.org/0000-0003-4295-4585 UNSPECIFIED Slebocki, Karin UNSPECIFIED UNSPECIFIED UNSPECIFIED Maintz, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Henning, Tobias D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lehmann, Helmar C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lichtenstein, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-152085
DOI:	10.1007/s00415-019-09224-0
Journal or Publication Title:	J. Neurol.
Volume:	266
Number:	4
Page Range:	S. 975 - 982
Date:	2019
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1432-1459
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DENSITY FAT FRACTION; REGENERATION; NEUROGRAPHY Multiple languages Clinical Neurology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15208