Universität zu Köln

Skoetz, Nicole, Goldkuhle, Marius, Weigl, Aaron, Dwan, Kerry, Labonte, Valerie, Dahm, Philipp ORCID: 0000-0003-2819-2553, Meerpohl, Joerg J., Djulbegovic, Benjamin and van Dalen, Elvira C. (2019). Methodological review showed correct absolute effect size estimates for time-to-event outcomes in less than one-third of cancer-related systematic reviews. J. Clin. Epidemiol., 108. S. 1 - 10. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1878-5921

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Abstract

Objectives: To evaluate in how many cancer-related Cochrane reviews hazard ratio (HR)-based absolute effects in summary of findings (SoF) tables have been correctly calculated and reported. Study Design and Setting: We identified all Cochrane cancer intervention reviews that reported an FIR for at least one outcome and provided a SoF table, published between January 2011 and December 2017 in the Cochrane Database of Systematic Reviews. Results: In 28 reviews (29%) of 96 included Cochrane reviews, absolute effects in the SoF tables were calculated in a correct manner. In 23 reviews (24%), absolute effects had been correctly calculated, but there was no explanation given why authors calculated event-free survival (e.g., overall survival) throughout the review but reported number of events in SoF tables (e.g., death). Twelve reviews (13%) provided incorrect absolute effects. For seven reviews (7%), it was unclear if absolute effects were correctly calculated. In 26 (27%) reviews, no absolute effects based on the given HR were calculated. Conclusions: In less than one-third of cancer-related Cochrane reviews, absolute effect size estimates were correctly calculated and reported. There is a need for guidance on how to calculate and report absolute effect estimates based on HR data. (C) 2018 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Skoetz, Nicole UNSPECIFIED UNSPECIFIED UNSPECIFIED Goldkuhle, Marius UNSPECIFIED UNSPECIFIED UNSPECIFIED Weigl, Aaron UNSPECIFIED UNSPECIFIED UNSPECIFIED Dwan, Kerry UNSPECIFIED UNSPECIFIED UNSPECIFIED Labonte, Valerie UNSPECIFIED UNSPECIFIED UNSPECIFIED Dahm, Philipp UNSPECIFIED orcid.org/0000-0003-2819-2553 UNSPECIFIED Meerpohl, Joerg J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Djulbegovic, Benjamin UNSPECIFIED UNSPECIFIED UNSPECIFIED van Dalen, Elvira C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-152481
DOI:	10.1016/j.jclinepi.2018.12.006
Journal or Publication Title:	J. Clin. Epidemiol.
Volume:	108
Page Range:	S. 1 - 10
Date:	2019
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1878-5921
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TREAT Multiple languages Health Care Sciences & Services; Public, Environmental & Occupational Health Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15248