Wunderle, Marius, Pretscher, Jutta, Brucker, Sara Y., Volz, Bernhard, Hartmann, Arndt, Fiessler, Cornelia, Hein, Alexander ORCID: 0000-0003-2601-3398, Haeberle, Lothar, Jud, Sebastian M., Lux, Michael P., Janni, Wolfgang, Loehberg, Christian R., Hartkopf, Andreas D., Walter, Christina B., Baake, Gerold, Fridman, Alexander, Malter, Wolfram, Wuerstlein, Rachel, Harbeck, Nadia, Hoffmann, Oliver, Kuemmel, Sherko, Martin, Bernhard, Thomssen, Christoph, Graf, Heiko, Wolf, Christopher, Bayer, Christian M., Hack, Carolin C., Almstedt, Katrin, Gass, Paul, Heindl, Felix ORCID: 0000-0002-5484-2575, Brodkorb, Tobias F., Nabieva, Naiba, Lindner, Christoph, Kolberg, Hans-Christian, Krabisch, Petra, Weigel, Michael, Steinfeld-Birg, Dieter, Kohls, Andreas, Brucker, Cosima, Schulz, Volker, Fischer, Gunnar, Pelzer, Volker, Wallwiener, Diethelm, Rack, Brigitte, Fehm, Tanja, Rody, Achim, Maass, Nicolai, Beckmann, Matthias W., Fasching, Peter A. and Rauh, Claudia (2019). Association between breast cancer risk factors and molecular type in postmenopausal patients with hormone receptor-positive early breast cancer. Breast Cancer Res. Treat., 174 (2). S. 453 - 462. NEW YORK: SPRINGER. ISSN 1573-7217

Full text not available from this repository.

Abstract

PurposeEvidence shows that genetic and non-genetic risk factors for breast cancer (BC) differ relative to the molecular subtype. This analysis aimed to investigate associations between epidemiological risk factors and immunohistochemical subtypes in a cohort of postmenopausal, hormone receptor-positive BC patients.MethodsThe prospective, single-arm, multicenter phase IV PreFace study (Evaluation of Predictive Factors Regarding the Effectivity of Aromatase Inhibitor Therapy) included 3529 postmenopausal patients with hormone receptor-positive early BC. Data on their epidemiological risk factors were obtained from patients' diaries and their medical histories. Data on estrogen receptor, progesterone receptor, and HER2 receptor status were obtained from pathology reports. Patients with incomplete information were excluded. Data were analyzed using conditional inference regression analysis, analysis of variance, and the chi-squared test.ResultsIn a cohort of 3392 patients, the strongest association with the molecular subtypes of BC was found for hormone replacement therapy (HRT) before diagnosis of early BC. The analysis showed that patients who took HRT at diagnosis had luminal A-like BC more often (83.7%) than those who had never taken HRT or had stopped taking it (75.5%). Luminal B-like BC and HER2-positive BC were diagnosed more often in women who had never taken HRT or had stopped taking it (13.3% and 11.2%, respectively) than in women who were taking HRT at diagnosis of BC (8.3% and 8.0%, respectively).ConclusionsThis analysis shows an association between HRT and the distribution of molecular subtypes of BC. However, no associations between other factors (e.g., age at diagnosis, body mass index, smoking status, age at menopause, number of deliveries, age at first delivery, breastfeeding history, or family history) were noted.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Wunderle, MariusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pretscher, JuttaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brucker, Sara Y.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Volz, BernhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hartmann, ArndtUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fiessler, CorneliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hein, AlexanderUNSPECIFIEDorcid.org/0000-0003-2601-3398UNSPECIFIED
Haeberle, LotharUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jud, Sebastian M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lux, Michael P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Janni, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Loehberg, Christian R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hartkopf, Andreas D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Walter, Christina B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baake, GeroldUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fridman, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Malter, WolframUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wuerstlein, RachelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Harbeck, NadiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoffmann, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuemmel, SherkoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martin, BernhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thomssen, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Graf, HeikoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wolf, ChristopherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bayer, Christian M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hack, Carolin C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Almstedt, KatrinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gass, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heindl, FelixUNSPECIFIEDorcid.org/0000-0002-5484-2575UNSPECIFIED
Brodkorb, Tobias F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nabieva, NaibaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lindner, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kolberg, Hans-ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krabisch, PetraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weigel, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steinfeld-Birg, DieterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kohls, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brucker, CosimaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schulz, VolkerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fischer, GunnarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pelzer, VolkerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wallwiener, DiethelmUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rack, BrigitteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fehm, TanjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rody, AchimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maass, NicolaiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beckmann, Matthias W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fasching, Peter A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rauh, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-153059
DOI: 10.1007/s10549-018-05115-6
Journal or Publication Title: Breast Cancer Res. Treat.
Volume: 174
Number: 2
Page Range: S. 453 - 462
Date: 2019
Publisher: SPRINGER
Place of Publication: NEW YORK
ISSN: 1573-7217
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
REPLACEMENT THERAPY; MAMMOGRAPHIC DENSITY; SUSCEPTIBILITY VARIANTS; ESTROGEN; WOMEN; PROGNOSIS; METAANALYSIS; CONSENSUS; SURVIVAL; SUBTYPESMultiple languages
OncologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/15305

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item