Universität zu Köln

Ray, Suparna, Rosenberg, Miriam, I, Chanut-Delalande, Helene, Decaras, Amelie, Schwertner, Barbara, Toubiana, William, Auman, Tzach ORCID: 0000-0002-2233-4234, Schnellhammer, Irene, Teuscher, Matthias ORCID: 0000-0003-2340-5716, Valenti, Philippe, Khila, Abderrahman, Klingler, Martin and Payre, Francois (2019). The mlpt/Ubr3/Svb module comprises an ancient developmental switch for embryonic patterning. eLife, 8. CAMBRIDGE: ELIFE SCIENCES PUBLICATIONS LTD. ISSN 2050-084X

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Abstract

Small open reading frames (smORFs) encoding 'micropeptides' exhibit remarkable evolutionary complexity. Conserved peptides encoded by mille-pattes (mlpt)/polished rice (pri)/tarsal less (tal) are essential for embryo segmentation in Tribolium but, in Drosophila, function in terminal epidermal differentiation and patterning of adult legs. Here, we show that a molecular complex identified in Drosophila epidermal differentiation, comprising Mlpt peptides, ubiquitinligase Ubr3 and transcription factor Shavenbaby (Svb), represents an ancient developmental module required for early insect embryo patterning. We find that loss of segmentation function for this module in flies evolved concomitantly with restriction of Svb expression in early Drosophila embryos. Consistent with this observation, artificially restoring early Svb expression in flies causes segmentation defects that depend on mlpt function, demonstrating enduring potency of an ancestral developmental switch despite evolving embryonic patterning modes. These results highlight the evolutionary plasticity of conserved molecular complexes under the constraints of essential genetic networks. Editorial note: This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (see decision letter).

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ray, Suparna UNSPECIFIED UNSPECIFIED UNSPECIFIED Rosenberg, Miriam, I UNSPECIFIED UNSPECIFIED UNSPECIFIED Chanut-Delalande, Helene UNSPECIFIED UNSPECIFIED UNSPECIFIED Decaras, Amelie UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwertner, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Toubiana, William UNSPECIFIED UNSPECIFIED UNSPECIFIED Auman, Tzach UNSPECIFIED orcid.org/0000-0002-2233-4234 UNSPECIFIED Schnellhammer, Irene UNSPECIFIED UNSPECIFIED UNSPECIFIED Teuscher, Matthias UNSPECIFIED orcid.org/0000-0003-2340-5716 UNSPECIFIED Valenti, Philippe UNSPECIFIED UNSPECIFIED UNSPECIFIED Khila, Abderrahman UNSPECIFIED UNSPECIFIED UNSPECIFIED Klingler, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Payre, Francois UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-153500
DOI:	10.7554/eLife.39748
Journal or Publication Title:	eLife
Volume:	8
Date:	2019
Publisher:	ELIFE SCIENCES PUBLICATIONS LTD
Place of Publication:	CAMBRIDGE
ISSN:	2050-084X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MORPHOLOGICAL EVOLUTION; SEGMENTATION GENE; SMALL PEPTIDES; MESSENGER-RNA; EVO-DEVO; DROSOPHILA; SHAVENBABY; EXPRESSION; GROWTH; NOTCH Multiple languages Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15350