Universität zu Köln

Brandt, Marie R., Vanasschen, Christian, Ermert, Johannes ORCID: 0000-0002-2561-7766, Coenen, Heinz H. and Neumaier, Bernd ORCID: 0000-0001-5425-3116 (2019). Mn-52g/55-Labelled CDTA-based trimeric complexes as novel bimodal PET/MR probes with high relaxivity. Dalton Trans., 48 (9). S. 3003 - 3009. CAMBRIDGE: ROYAL SOC CHEMISTRY. ISSN 1477-9234

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Abstract

trans-1,2-Diaminocyclohexane-N,N,N,N-tetraacetic acid (CDTA) labelled with a mixture of paramagnetic Mn-55(ii) and (+)-emitting Mn-52g(ii) offers access to bimodal Positron Emission Tomography/Magnetic Resonance (PET/MR) tracers. To enhance the number of NMR-active nuclei and simultaneously improve the longitudinal relaxivity r(1), a complex composed of three CDTA units was designed. Accordingly, a functionalised tris-CDTA-1,3,5-tris-triazolobenzene was prepared and labelled with c.a. and n.c.a. Mn-52g. Relaxivity measurements of the Mn-55-complex showed an enhancement of r(1) of 144% in comparison to the Mn-CDTA monomer. Moreover, the trimer was equipped with an additional linker functionality suitable for conjugation with biomolecules, enabling interaction with specific molecular targets.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Brandt, Marie R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vanasschen, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Ermert, Johannes UNSPECIFIED orcid.org/0000-0002-2561-7766 UNSPECIFIED Coenen, Heinz H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Neumaier, Bernd UNSPECIFIED orcid.org/0000-0001-5425-3116 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-154083
DOI:	10.1039/c8dt04996c
Journal or Publication Title:	Dalton Trans.
Volume:	48
Number:	9
Page Range:	S. 3003 - 3009
Date:	2019
Publisher:	ROYAL SOC CHEMISTRY
Place of Publication:	CAMBRIDGE
ISSN:	1477-9234
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language O-17 NMR; MN2+ COMPLEXES; WATER EXCHANGE; MANGANESE(II); LIGANDS; SYSTEM; MN-52; MRI Multiple languages Chemistry, Inorganic & Nuclear Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15408