Universität zu Köln

Zittermann, Armin ORCID: 0000-0001-6085-6554, Ernst, Jana B., Prokop, Sylvana, Fuchs, Uwe, Dreier, Jens, Kuhn, Joachim, Knabbe, Cornelius, Berthold, Heiner K., Gouni-Berthold, Ioanna, Gummert, Jan F., Boergermann, Jochen and Pilz, Stefan ORCID: 0000-0002-7959-1311 (2019). Vitamin D supplementation does not prevent the testosterone decline in males with advanced heart failure: the EVITA trial. Eur. J. Nutr., 58 (2). S. 673 - 681. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1436-6215

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Abstract

PurposeObservational studies indicate a positive association between circulating 25-hydroxyvitamin D (25OHD) and testosterone (T) concentrations. Because low 25OHD concentrations and T deficiency are considered to be a generalized phenomenon in patients with advanced heart failure (HF), we aimed to investigate whether vitamin D supplementation has beneficial effects on T indices in these patients.MethodsIn a pre-specified secondary analysis of the EVITA (effect of vitamin D on mortality in heart failure) randomized controlled trial, we analyzed in male subjects with 25OHD concentrations<75nmol/L the effect of a daily vitamin D-3 supplement of 4000IU for 3years (n=71) vs. placebo (n=62) on total T (TT), sex hormone-binding globulin (SHBG), free T (fT), and bioactive T (BAT). We assessed changes from baseline until study termination and between-group differences at study termination.Results25OHD increased in the placebo group from 36.6nmol/L by 9.2nmol/L (95% CI 3.2-15.1nmol/L; P=0.003) and in the vitamin D group from 36.5nmol/L by 63.9nmol/L (95% CI 52.6-75.3nmol/L; P<0.001), with a significant between-group difference at study termination (P<0.001). TT and SHBG concentrations did not change significantly, neither in the placebo group nor in the vitamin D group (P=0.845-0.082), but concentrations of fT and BAT declined significantly in both groups (P=0.025-0.008). At study termination, there were no between-group differences in TT (P=0.612), SHBG (P=0.393), fT (P=0.861), or BAT (P=0.960).ConclusionsIn male patients with advanced HF and low 25OHD concentrations, a daily vitamin D-3 supplement of 4000IU for 3years did not prevent the decline in testosterone indices.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zittermann, Armin UNSPECIFIED orcid.org/0000-0001-6085-6554 UNSPECIFIED Ernst, Jana B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Prokop, Sylvana UNSPECIFIED UNSPECIFIED UNSPECIFIED Fuchs, Uwe UNSPECIFIED UNSPECIFIED UNSPECIFIED Dreier, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuhn, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Knabbe, Cornelius UNSPECIFIED UNSPECIFIED UNSPECIFIED Berthold, Heiner K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gouni-Berthold, Ioanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Gummert, Jan F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Boergermann, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Pilz, Stefan UNSPECIFIED orcid.org/0000-0002-7959-1311 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-154915
DOI:	10.1007/s00394-018-1666-5
Journal or Publication Title:	Eur. J. Nutr.
Volume:	58
Number:	2
Page Range:	S. 673 - 681
Date:	2019
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1436-6215
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SERUM 25-HYDROXYVITAMIN D; D DEFICIENCY; ASSOCIATION; MEN; HORMONES Multiple languages Nutrition & Dietetics Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15491