Universität zu Köln

Sanchez-Ruiz, Monica, Polakos, Noelle Katherine, Blau, Tobias, Utermoehlen, Olaf, Brunn, Anna, Montesinos-Rongen, Manuel, Huenig, Thomas and Deckert, Martina (2019). TLR signals license CD8 T cells to destroy oligodendrocytes expressing an antigen shared with a Listeria pathogen. Eur. J. Immunol., 49 (3). S. 413 - 428. HOBOKEN: WILEY. ISSN 1521-4141

Full text not available from this repository.

Abstract

Increasing evidence suggests a role of CD8 T cells in autoimmune demyelinating CNS disease, which, however, is still controversially discussed. Mice, which express ovalbumin (OVA) as cytosolic self-antigen in oligodendrocytes (ODC-OVA mice), respond to CNS infection induced by OVA-expressing attenuated Listeria with CD8 T cell-mediated inflammatory demyelination. This model is suitable to decipher the contribution of CD8 T cells and the pathogen in autoimmune CNS disease. Here, we show that both antigen and pathogen are required in the CNS for disease induction, though not in a physically linked fashion. Intracerebral challenge with combined toll like receptor (TLR) TLR2 and TLR9 as well as TLR7 and TLR9 agonists substituted for the bacterial stimulus, but not with individual TLR agonists (TLR2, TLR3,TLR5,TLR7, TLR9). Furthermore, MyD88 inactivation rendered ODC-OVA mice resistant to disease induction. Collectively, CD8 T cell-mediated destruction of oligodendrocytes is activated if (i) an antigen shared with an infectious agent is provided in the CNS microenvironment and (ii) innate immune signals inform the CNS microenvironment that pathogen removal warrants an immune attack by CD8 T cells, even at the expense of locally restricted demyelination.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sanchez-Ruiz, Monica UNSPECIFIED UNSPECIFIED UNSPECIFIED Polakos, Noelle Katherine UNSPECIFIED UNSPECIFIED UNSPECIFIED Blau, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Utermoehlen, Olaf UNSPECIFIED UNSPECIFIED UNSPECIFIED Brunn, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Montesinos-Rongen, Manuel UNSPECIFIED UNSPECIFIED UNSPECIFIED Huenig, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Deckert, Martina UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-155548
DOI:	10.1002/eji.201847834
Journal or Publication Title:	Eur. J. Immunol.
Volume:	49
Number:	3
Page Range:	S. 413 - 428
Date:	2019
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1521-4141
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CENTRAL-NERVOUS-SYSTEM; TOLL-LIKE RECEPTORS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; MULTIPLE-SCLEROSIS; IMMUNE-RESPONSES; DISEASE; INNATE; MODEL; ACTIVATION; MECHANISMS Multiple languages Immunology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15554