Universität zu Köln

Schober, Lukas, Ratnam, Shahilan, Yamashita, Yasunobu, Adebar, Niklas ORCID: 0000-0003-3776-2255, Pieper, Matthias, Berkessel, Albrecht ORCID: 0000-0003-0470-7428, Hessel, Volker ORCID: 0000-0002-9494-1519 and Groeger, Harald (2019). An Asymmetric Organocatalytic Aldol Reaction of a Hydrophobic Aldehyde in Aqueous Medium Running in Flow Mode. Synthesis, 51 (5). S. 1178 - 1185. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1437-210X

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Abstract

Reaction conditions have been identified to conduct a one-pot asymmetric organocatalytic aldol reaction with a hydrophobic substrate in aqueous medium via a process running in flow mode. By employing a mixture of water and 2-propanol, a hydrophobic aldehyde and 3.6 mol% of an organocatalyst, this microreactor process affords the desired aldol adduct with a conversion of 74% and an enantioselectivity of 89% after a reaction time of 60 minutes.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schober, Lukas UNSPECIFIED UNSPECIFIED UNSPECIFIED Ratnam, Shahilan UNSPECIFIED UNSPECIFIED UNSPECIFIED Yamashita, Yasunobu UNSPECIFIED UNSPECIFIED UNSPECIFIED Adebar, Niklas UNSPECIFIED orcid.org/0000-0003-3776-2255 UNSPECIFIED Pieper, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Berkessel, Albrecht UNSPECIFIED orcid.org/0000-0003-0470-7428 UNSPECIFIED Hessel, Volker UNSPECIFIED orcid.org/0000-0002-9494-1519 UNSPECIFIED Groeger, Harald UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-155734
DOI:	10.1055/s-0037-1610404
Journal or Publication Title:	Synthesis
Volume:	51
Number:	5
Page Range:	S. 1178 - 1185
Date:	2019
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1437-210X
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Organic Chemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COMBINATION; CATALYSTS Multiple languages Chemistry, Organic Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15573