Colijn, Johanna M., den Hollander, Anneke, I, Demirkan, Ayse ORCID: 0000-0002-7546-0867, Cougnard-Gregoire, Audrey, Verzijden, Timo, Kersten, Eveline, Meester-Smoor, Magda A., Merle, Benedicte M. J., Papageorgiou, Grigorios, Ahmad, Shahzad ORCID: 0000-0002-8658-3790, Mulder, Monique T., Costa, Miguel Angelo, Benlian, Pascale, Bertelsen, Geir, Bron, Alain M., Claes, Birte, Creuzot-Garcher, Catherine, Erke, Maja Gran, Fauser, Sascha, Foster, Paul J., Hammond, Christopher J., Hense, Hans-Werner, Hoyng, Carel B., Khawaja, Anthony P., Korobelnik, Jean-Francois, Piermarocchi, Stefano, Segato, Tatiana, Silva, Rufino, Souied, Eric H., Williams, Katie M., van Duijn, Cornelia M., Delcourt, Cecile ORCID: 0000-0002-2099-0481, Klaver, Caroline C. W., Acar, Niyazi, Altay, Lebriz, Anastosopoulos, Eleftherios, Azuara-Blanco, Augusto ORCID: 0000-0002-4805-9322, Berendschot, Tos, Bergen, Arthur, Binquet, Christine, Bird, Alan, Bobak, Martin ORCID: 0000-0002-2633-6851, Larsen, Morten Bogelund, Boon, Camiel, Bourne, Rupert, Bretillon, Lionel, Broe, Rebecca, Bron, Alain ORCID: 0000-0002-7265-931X, Buitendijk, Gabrielle, Cachulo, Maria Luz, Capuano, Vittorio, Carriere, Isabelle, Chakravarthy, Usha, Chan, Michelle, Chang, Petrus, Colijn, Johanna, Cree, Angela ORCID: 0000-0002-1987-8900, Cumberland, Phillippa, Cunha-Vaz, Jose ORCID: 0000-0002-0947-9850, Daien, Vincent, De Jong, Eiko, Deak, Gabor, Delyfer, Marie-Noelle, den Hollander, Anneke, Dietzel, Martha, Faria, Pedro, Farinha, Claudia ORCID: 0000-0003-4596-0913, Finger, Robert, Fletcher, Astrid, Foster, Paul ORCID: 0000-0002-4755-177X, Founti, Panayiota, Gorgels, Theo, Grauslund, Jakob ORCID: 0000-0001-5019-0736, Grus, Franz, Hammond, Christopher ORCID: 0000-0002-3227-2620, Heesterbeek, Thomas, Hermann, Manuel, Hoehn, Rene, Hogg, Ruth ORCID: 0000-0001-9413-2669, Holz, Frank, Hoyng, Carel, Jansonius, Nomdo, Janssen, Sarah, de Jonga, Eiko, Khawaja, Anthony ORCID: 0000-0001-6802-8585, Klaver, Caroline, Lamparter, Julia, Le Goff, Melanie, Lehtimaki, Terho, Leung, Irene, Lotery, Andrew ORCID: 0000-0001-5541-4305, Mauschitz, Matthias, Meester, Magda, Merle, Benedicte, Westrup, Verena Meyer Zu, Midena, Edoardo, Miotto, Stefania, Mirshahi, Alireza, Mohan-Said, Sadek, Mueller, Michael, Muldrew, Alyson, Murta, Joaquim ORCID: 0000-0001-8926-5176, Nickels, Stefan, Nunes, Sandrina, Owen, Christopher, Peto, Tunde, Pfeiffer, Norbert, Prokofyeva, Elena, Rahi, Jugnoo ORCID: 0000-0002-5718-9209, Raitakari, Olli, Rauscher, Franziska, Ribeiro, Luisa, Rougier, Marie-Benedicte, Rudnicka, Alicja, Sahel, Jose, Salonikiou, Aggeliki, Sanchez, Clarisa, Schick, Tina, Schmitz-Valckenberg, Steffen, Schuster, Alexander, Schweitzer, Cedric, Shehata, Jasmin, Silvestri, Giuliana, Simader, Christian, Souied, Eric, Speckauskas, Martynas, Springelkamp, Henriet, Tapp, Robyn, Topouzis, Fotis, van Leeuwen, Elisa, Verhoeven, Virginie, Vingerling, Hans, Von Hanno, Therese, Williams, Katie, Wolfram, Christian, Yip, Jennifer, Zerbib, Jennyfer, Ajana, Soufiane, Arango-Gonzalez, Blanca, Arndt, Verena, Bhatia, Vaibhav, Bhattacharya, Shomi S., Biarnes, Marc ORCID: 0000-0003-2584-4894, Borrell, Anna, Buehren, Sebastian, Calado, Sofia M. ORCID: 0000-0001-5509-4145, Dammeier, Sascha, de Jong, Eiko K., De la Cerda, Berta, Diaz-Corrales, Francisco J. ORCID: 0000-0002-5752-0205, Diether, Sigrid, Emri, Eszter, Endermann, Tanja, Ferraro, Lucia L., Garcia, Miriam, Heesterbeek, Thomas J., Honisch, Sabina, Kilger, Ellen, Langen, Hanno, Lengyel, Imre ORCID: 0000-0001-7467-2174, Luthert, Phil, Maugeais, Cyrille, Meester-Smoor, Magda, Inserm, Benedicte M. J. Merle, Mones, Jordi ORCID: 0000-0003-3685-2160, Nogoceke, Everson, Pool, Frances M., Rodriguez, Eduardo, Ueffing, Marius, Bartz-Schmidt, Karl U. Ulrich, van Leeuwen, Elisabeth M. and Zumbansen, Markus (2019). Increased High-Density Lipoprotein Levels Associated with Age-Related Macular Degeneration Evidence from the EYE-RISK and European Eye Epidemiology Consortia. Ophthalmology, 126 (3). S. 393 - 407. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1549-4713

Full text not available from this repository.

Abstract

Purpose: Genetic and epidemiologic studies have shown that lipid genes and high-density lipoproteins (HDLs) are implicated in age-related macular degeneration (AMD). We studied circulating lipid levels in relationship to AMD in a large European dataset. Design: Pooled analysis of cross-sectional data. Participants: Individuals (N = 30 953) aged 50 years or older participating in the European Eye Epidemiology (E3) consortium and 1530 individuals from the Rotterdam Study with lipid subfraction data. Methods: AMD features were graded on fundus photographs using the Rotterdam classification. Routine blood lipid measurements, genetics, medication, and potential confounders were extracted from the E3 database. In a subgroup of the Rotterdam Study, lipid subfractions were identified by the Nightingale biomarker platform. Random-intercepts mixed-effects models incorporating confounders and study site as a random effect were used to estimate associations. Main Outcome Measures: AMD features and stage; lipid measurements. Results: HDL was associated with an increased risk of AMD (odds ratio [OR], 1.21 per 1-mmol/l increase; 95% confidence interval [CI], 1.14-1.29), whereas triglycerides were associated with a decreased risk (OR, 0.94 per 1-mmol/l increase; 95% CI, 0.91-0.97). Both were associated with drusen size. Higher HDL raised the odds of larger drusen, whereas higher triglycerides decreases the odds. LDL cholesterol reached statistical significance only in the association with early AMD (P = 0.045). Regarding lipid subfractions, the concentration of extra-large HDL particles showed the most prominent association with AMD (OR, 1.24; 95% CI, 1.10-1.40). The cholesteryl ester transfer protein risk variant (rs17231506) for AMD was in line with increased HDL levels (P = 7.7 x 10(-7)), but lipase C risk variants (rs2043085, rs2070895) were associated in an opposite way (P = 1.0 x 10(-6) and P = 1.6 x 10(-4)). Conclusions: Our study suggested that HDL cholesterol is associated with increased risk of AMD and that triglycerides are negatively associated. Both show the strongest association with early AMD and drusen. Extra-large HDL subfractions seem to be drivers in the relationship with AMD, and variants in lipid genes play a more ambiguous role in this association. Whether systemic lipids directly influence AMD or represent lipid metabolism in the retina remains to be answered. (C) 2018 by the American Academy of Ophthalmology

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Colijn, Johanna M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
den Hollander, Anneke, IUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Demirkan, AyseUNSPECIFIEDorcid.org/0000-0002-7546-0867UNSPECIFIED
Cougnard-Gregoire, AudreyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Verzijden, TimoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kersten, EvelineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meester-Smoor, Magda A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Merle, Benedicte M. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Papageorgiou, GrigoriosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ahmad, ShahzadUNSPECIFIEDorcid.org/0000-0002-8658-3790UNSPECIFIED
Mulder, Monique T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Costa, Miguel AngeloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Benlian, PascaleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bertelsen, GeirUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bron, Alain M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Claes, BirteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Creuzot-Garcher, CatherineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Erke, Maja GranUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fauser, SaschaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Foster, Paul J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hammond, Christopher J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hense, Hans-WernerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoyng, Carel B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Khawaja, Anthony P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Korobelnik, Jean-FrancoisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Piermarocchi, StefanoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Segato, TatianaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Silva, RufinoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Souied, Eric H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Williams, Katie M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Duijn, Cornelia M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Delcourt, CecileUNSPECIFIEDorcid.org/0000-0002-2099-0481UNSPECIFIED
Klaver, Caroline C. W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Acar, NiyaziUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Altay, LebrizUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Anastosopoulos, EleftheriosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Azuara-Blanco, AugustoUNSPECIFIEDorcid.org/0000-0002-4805-9322UNSPECIFIED
Berendschot, TosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bergen, ArthurUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Binquet, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bird, AlanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bobak, MartinUNSPECIFIEDorcid.org/0000-0002-2633-6851UNSPECIFIED
Larsen, Morten BogelundUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boon, CamielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bourne, RupertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bretillon, LionelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Broe, RebeccaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bron, AlainUNSPECIFIEDorcid.org/0000-0002-7265-931XUNSPECIFIED
Buitendijk, GabrielleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cachulo, Maria LuzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Capuano, VittorioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carriere, IsabelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chakravarthy, UshaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chan, MichelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chang, PetrusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Colijn, JohannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cree, AngelaUNSPECIFIEDorcid.org/0000-0002-1987-8900UNSPECIFIED
Cumberland, PhillippaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cunha-Vaz, JoseUNSPECIFIEDorcid.org/0000-0002-0947-9850UNSPECIFIED
Daien, VincentUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De Jong, EikoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Deak, GaborUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Delyfer, Marie-NoelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
den Hollander, AnnekeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dietzel, MarthaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Faria, PedroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Farinha, ClaudiaUNSPECIFIEDorcid.org/0000-0003-4596-0913UNSPECIFIED
Finger, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fletcher, AstridUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Foster, PaulUNSPECIFIEDorcid.org/0000-0002-4755-177XUNSPECIFIED
Founti, PanayiotaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gorgels, TheoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grauslund, JakobUNSPECIFIEDorcid.org/0000-0001-5019-0736UNSPECIFIED
Grus, FranzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hammond, ChristopherUNSPECIFIEDorcid.org/0000-0002-3227-2620UNSPECIFIED
Heesterbeek, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hermann, ManuelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoehn, ReneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hogg, RuthUNSPECIFIEDorcid.org/0000-0001-9413-2669UNSPECIFIED
Holz, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoyng, CarelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jansonius, NomdoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Janssen, SarahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Jonga, EikoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Khawaja, AnthonyUNSPECIFIEDorcid.org/0000-0001-6802-8585UNSPECIFIED
Klaver, CarolineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lamparter, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Le Goff, MelanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lehtimaki, TerhoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leung, IreneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lotery, AndrewUNSPECIFIEDorcid.org/0000-0001-5541-4305UNSPECIFIED
Mauschitz, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meester, MagdaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Merle, BenedicteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Westrup, Verena Meyer ZuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Midena, EdoardoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Miotto, StefaniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mirshahi, AlirezaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mohan-Said, SadekUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muldrew, AlysonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Murta, JoaquimUNSPECIFIEDorcid.org/0000-0001-8926-5176UNSPECIFIED
Nickels, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nunes, SandrinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Owen, ChristopherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peto, TundeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfeiffer, NorbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prokofyeva, ElenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rahi, JugnooUNSPECIFIEDorcid.org/0000-0002-5718-9209UNSPECIFIED
Raitakari, OlliUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rauscher, FranziskaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ribeiro, LuisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rougier, Marie-BenedicteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rudnicka, AlicjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sahel, JoseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Salonikiou, AggelikiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sanchez, ClarisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schick, TinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmitz-Valckenberg, SteffenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schuster, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schweitzer, CedricUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shehata, JasminUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Silvestri, GiulianaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Simader, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Souied, EricUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Speckauskas, MartynasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Springelkamp, HenrietUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tapp, RobynUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Topouzis, FotisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Leeuwen, ElisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Verhoeven, VirginieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vingerling, HansUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Von Hanno, ThereseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Williams, KatieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wolfram, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yip, JenniferUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zerbib, JennyferUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ajana, SoufianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arango-Gonzalez, BlancaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arndt, VerenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bhatia, VaibhavUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bhattacharya, Shomi S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Biarnes, MarcUNSPECIFIEDorcid.org/0000-0003-2584-4894UNSPECIFIED
Borrell, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buehren, SebastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Calado, Sofia M.UNSPECIFIEDorcid.org/0000-0001-5509-4145UNSPECIFIED
Dammeier, SaschaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Jong, Eiko K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De la Cerda, BertaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Diaz-Corrales, Francisco J.UNSPECIFIEDorcid.org/0000-0002-5752-0205UNSPECIFIED
Diether, SigridUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Emri, EszterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Endermann, TanjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ferraro, Lucia L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garcia, MiriamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heesterbeek, Thomas J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Honisch, SabinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kilger, EllenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Langen, HannoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lengyel, ImreUNSPECIFIEDorcid.org/0000-0001-7467-2174UNSPECIFIED
Luthert, PhilUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maugeais, CyrilleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meester-Smoor, MagdaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Inserm, Benedicte M. J. MerleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mones, JordiUNSPECIFIEDorcid.org/0000-0003-3685-2160UNSPECIFIED
Nogoceke, EversonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pool, Frances M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rodriguez, EduardoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ueffing, MariusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bartz-Schmidt, Karl U. UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Leeuwen, Elisabeth M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zumbansen, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-155895
DOI: 10.1016/j.ophtha.2018.09.045
Journal or Publication Title: Ophthalmology
Volume: 126
Number: 3
Page Range: S. 393 - 407
Date: 2019
Publisher: ELSEVIER SCIENCE INC
Place of Publication: NEW YORK
ISSN: 1549-4713
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
GENOME-WIDE ASSOCIATION; HEPATIC LIPASE; STATIN USE; CHOLESTEROL; PLASMA; MACULOPATHY; DRUSEN; PROGRESSION; ACTIVATION; PROTEINSMultiple languages
OphthalmologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/15589

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