Universität zu Köln

Wagener, Rabea, Seufert, Julian, Raimondi, Francesco, Bens, Susanne, Kleinheinz, Kortine, Nagel, Inga, Altmueller, Janine, Thiele, Holger, Huebschmann, Daniel, Kohler, Christian W., Nuernberg, Peter, Au-Yeung, Rex, Burkhardt, Birgit, Horn, Heike, Leoncini, Lorenzo, Jaffe, Elaine S., Ott, German, Rymkiewicz, Grzegorz ORCID: 0000-0002-3478-8014, Schlesner, Matthias ORCID: 0000-0002-5896-4086, Russell, Robert B., Klapper, Wolfram and Siebert, Reiner (2019). The mutational landscape of Burkitt-like lymphoma with 11q aberration is distinct from that of Burkitt lymphoma. Blood, 133 (9). S. 962 - 967. WASHINGTON: AMER SOC HEMATOLOGY. ISSN 1528-0020

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Abstract

The new recently described provisional lymphoma category Burkitt-like lymphoma with 11q aberration comprises cases similar to Burkitt lymphoma (BL) on morphological, immunophenotypic and gene-expression levels but lacking the IG-MYC translocation. They are characterized by a peculiar imbalance pattern on chromosome 11, but the landscape of mutations is not yet described. Thus, we investigated 15 MYC-negative Burkitt-like lymphoma with 11q aberration (mnBLL, 11q,) cases by copy-number analysis and whole-exome sequencing. We refined the regions of 11q imbalance and identified the INO80 complex-associated gene NFRKB as a positional candidate in 11q24.3. Next to recurrent gains in 12q13.11-q24.32 and 7q34-qter as well as losses in 13q32.3-q34, we identified 47 genes recurrently affected by protein-changing mutations (each >= 3 of 15 cases). Strikingly, we did not detect recurrent mutations in genes of the ID3-TCF3 axis or the SWI/SNF complex that are frequently altered in BL, or in genes frequently mutated in germinal center-derived B-cell lymphomas like KMT2D or CREBBP. An exception is GNA13, which was mutated in 7 of 15 cases. We conclude that the genomic landscape of mnBLL, 11q, differs from that of BL both at the chromosomal and mutational levels. Our findings implicate that mnBLL, 11q, is a lymphoma category distinct from BL at the molecular level.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wagener, Rabea UNSPECIFIED UNSPECIFIED UNSPECIFIED Seufert, Julian UNSPECIFIED UNSPECIFIED UNSPECIFIED Raimondi, Francesco UNSPECIFIED UNSPECIFIED UNSPECIFIED Bens, Susanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Kleinheinz, Kortine UNSPECIFIED UNSPECIFIED UNSPECIFIED Nagel, Inga UNSPECIFIED UNSPECIFIED UNSPECIFIED Altmueller, Janine UNSPECIFIED UNSPECIFIED UNSPECIFIED Thiele, Holger UNSPECIFIED UNSPECIFIED UNSPECIFIED Huebschmann, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Kohler, Christian W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nuernberg, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Au-Yeung, Rex UNSPECIFIED UNSPECIFIED UNSPECIFIED Burkhardt, Birgit UNSPECIFIED UNSPECIFIED UNSPECIFIED Horn, Heike UNSPECIFIED UNSPECIFIED UNSPECIFIED Leoncini, Lorenzo UNSPECIFIED UNSPECIFIED UNSPECIFIED Jaffe, Elaine S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ott, German UNSPECIFIED UNSPECIFIED UNSPECIFIED Rymkiewicz, Grzegorz UNSPECIFIED orcid.org/0000-0002-3478-8014 UNSPECIFIED Schlesner, Matthias UNSPECIFIED orcid.org/0000-0002-5896-4086 UNSPECIFIED Russell, Robert B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klapper, Wolfram UNSPECIFIED UNSPECIFIED UNSPECIFIED Siebert, Reiner UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-156196
DOI:	10.1182/blood-2018-07-864025
Journal or Publication Title:	Blood
Volume:	133
Number:	9
Page Range:	S. 962 - 967
Date:	2019
Publisher:	AMER SOC HEMATOLOGY
Place of Publication:	WASHINGTON
ISSN:	1528-0020
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language B-CELL LYMPHOMAS; HETEROGENEITY; GENOME Multiple languages Hematology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15619