Universität zu Köln

Kohl, Sina, Hannah, Ricci ORCID: 0000-0001-5379-3292, Rocchi, Lorenzo ORCID: 0000-0003-3979-156X, Nord, Camilla L., Rothwell, John ORCID: 0000-0003-1367-6467 and Voon, Valerie (2019). Cortical Paired Associative Stimulation Influences Response Inhibition: Cortico-cortical and Cortico-subcortical Networks. Biol. Psychiatry, 85 (4). S. 355 - 364. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1873-2402

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Abstract

BACKGROUND: The ability to stop a suboptimal response is integral to decision making and is commonly impaired across psychiatric disorders. Cortical paired associative stimulation (cPAS) is a form of transcranial magnetic stimulation in which paired pulses can induce plasticity at cortical synapses. Here we used cPAS protocols to target cortico-cortical and cortico-subcortical networks by using different intervals between the paired pulses in an attempt to modify response inhibition. METHODS: A total of 25 healthy volunteers underwent four cPAS sessions in random order 1 week apart: right inferior frontal cortex (IFC) stimulation preceding right presupplementary motor area (pre-SMA) stimulation by 10 or 4 ms and pre-SMA stimulation preceding IFC stimulation by 10 or 4 ms. Subjects were tested on the stop signal task along with the delay discounting task as control at baseline (randomized across sessions and cPAS protocol) and after each cPAS session. RESULTS: The stop signal reaction time showed a main effect of cPAS condition when controlling for age (F-3,F-57 = 4.05, p = .01). Younger subjects had greater impairments in response inhibition when the pre-SMA pulse preceded the IFC pulse by 10 ms. In older individuals, response inhibition improved when the IFC pulse preceded the pre-SMA pulse by 4 ms. There were no effects on delay discounting. CONCLUSIONS: cPAS modified response inhibition through age-dependent long-term potentiation and depression-like plasticity mechanisms via putative cortico-cortical and cortico-subcortical networks. We show for the first time the capacity for cPAS to modify a cognitive process highly relevant to psychiatric disorders.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kohl, Sina UNSPECIFIED UNSPECIFIED UNSPECIFIED Hannah, Ricci UNSPECIFIED orcid.org/0000-0001-5379-3292 UNSPECIFIED Rocchi, Lorenzo UNSPECIFIED orcid.org/0000-0003-3979-156X UNSPECIFIED Nord, Camilla L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rothwell, John UNSPECIFIED orcid.org/0000-0003-1367-6467 UNSPECIFIED Voon, Valerie UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-156598
DOI:	10.1016/j.biopsych.2018.03.009
Journal or Publication Title:	Biol. Psychiatry
Volume:	85
Number:	4
Page Range:	S. 355 - 364
Date:	2019
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1873-2402
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEEP-BRAIN-STIMULATION; POSTERIOR PARIETAL CORTEX; AGE-DEPENDENT CHANGES; HUMAN MOTOR CORTEX; PLASTICITY INDUCTION; SUBTHALAMIC NUCLEUS; ANTERIOR CINGULATE; ORGANIZATION; INCREASES; ABILITY Multiple languages Neurosciences; Psychiatry Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15659