Werner, Jan-Michael, Schweinsberg, Viola, Schroeter, Michael, von Reutern, Boris, Malter, Michael P., Schlaak, Max, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Mauch, Cornelia and Galldiks, Norbert ORCID: 0000-0002-2485-1796 (2019). Successful Treatment of Myasthenia Gravis Following PD-1/CTLA-4 Combination Checkpoint Blockade in a Patient With Metastatic Melanoma. Front. Oncol., 9. LAUSANNE: FRONTIERS MEDIA SA. ISSN 2234-943X

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Abstract

Currently, the blockade of certain immune checkpoints such as the cytotoxic T-Iymphocyte-associated protein 4 (CTLA-4) and programmed cell death-1 (PD-1) using checkpoint inhibitors is standard of care in patients with metastatic melanoma, especially with BRAF wild-type. However, several checkpoint inhibitor-related complications have been reported, including severe adverse events in the central and peripheral nervous system. In particular, in the recent past, the occurrence of myasthenia gravis following checkpoint inhibitor monotherapy, particularly nivolumab or ipilimumab, has been reported. In contrast, reports on PD-1/CTLA-4 combination blockade-usually with fatal clinical outcome-are scarce. We here report a case with combination immune checkpoint blockade-related myasthenia gravis with favorable clinical outcome.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Werner, Jan-MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schweinsberg, ViolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schroeter, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Reutern, BorisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Malter, Michael P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schlaak, MaxUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fink, Gereon R.UNSPECIFIEDorcid.org/0000-0002-8230-1856UNSPECIFIED
Mauch, CorneliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Galldiks, NorbertUNSPECIFIEDorcid.org/0000-0002-2485-1796UNSPECIFIED
URN: urn:nbn:de:hbz:38-156622
DOI: 10.3389/fonc.2019.00084
Journal or Publication Title: Front. Oncol.
Volume: 9
Date: 2019
Publisher: FRONTIERS MEDIA SA
Place of Publication: LAUSANNE
ISSN: 2234-943X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
NIVOLUMAB; IPILIMUMABMultiple languages
OncologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/15662

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