Universität zu Köln

Meuser, T., Ameis, A. and Lehmann, K. A. (2019). Red-haired patients and risk in anaesthesia and pain medicine - a critical analysis of the literature. Anasthesiol. Intensivmed., 60. S. 57 - 65. EBELSBACH: AKTIV DRUCK & VERLAG GMBH. ISSN 1439-0256

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Abstract

Physicians around the world often believe that red-haired people have to expect special complications in their disease. Critical voices reject such assumptions as superstitions, while others firmly insist on their personal experiences. Serious scientific investigations are very rare. A relationship between redheadedness and an increased anxiety about toothache and dental treatment has been described, similar findings were also reported for the reduced effectiveness of midazolam. There are also individual observations of effects induced by inhalation anaesthetics, whereas opioids have been discussed to have greater potency. In the present work, a relevant selection of the currently available research results from the literature is presented and critically analysed with regard to its clinical significance. Psychological studies suggest that redheads with melanocortin receptor defect mutations are more fearful than dark-haired patients. Midazolarn appeared to be slightly less effective in phenotypic red-haired persons in the scope of experimental sedation. For desflurane, the MAC values determined by electrical skin irritation in experimental anaesthesia were significantly higher by 19% in red-haired women with melanocortin receptor mutations than in the brown-haired control group. In cases of experimental heat-induced and ischaemic pain the opioid pentazocine is more potent in red-haired individuals with melanocortin receptor defect mutations. On the basis of this poor data situation, generalised warnings of particular risks in red-haired patients are not tenable. The fact that red-haired patients and red-haired female patients in particular have an increased risk for complications in anaesthesia or pain therapy cannot be confirmed by the available literature. The current data suggest that the relationship between redheadedness and clinical risk should be rejected.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Meuser, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ameis, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lehmann, K. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-157106
DOI:	10.19224/ai2019.057
Journal or Publication Title:	Anasthesiol. Intensivmed.
Volume:	60
Page Range:	S. 57 - 65
Date:	2019
Publisher:	AKTIV DRUCK & VERLAG GMBH
Place of Publication:	EBELSBACH
ISSN:	1439-0256
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MELANOCORTIN 1 RECEPTOR; BRITTLE CORNEA SYNDROME; EARLY-ONSET OBESITY; GENE; PIGMENTATION; COLOR; ANALGESIA; VARIANTS; MC1R; MICE Multiple languages Anesthesiology; Critical Care Medicine Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15710