Universität zu Köln

Chipurupalli, Sandhya, Kannan, Elango, Tergaonkar, Vinay, D'Andrea, Richard and Robinson, Nirmal ORCID: 0000-0002-7361-9491 (2019). Hypoxia Induced ER Stress Response as an Adaptive Mechanism in Cancer. Int. J. Mol. Sci., 20 (3). BASEL: MDPI. ISSN 1422-0067

Full text not available from this repository.

Abstract

It is evident that regions within tumors are deprived of oxygen, which makes the microenvironment hypoxic. Cancer cells experiencing hypoxia undergo metabolic alterations and cytoprotective adaptive mechanisms to survive such stringent conditions. While such mechanisms provide potential therapeutic targets, the mechanisms by which hypoxia regulates adaptive responsessuch as ER stress response, unfolded protein response (UPR), anti-oxidative responses, and autophagyremain elusive. In this review, we summarize the complex interplay between hypoxia and the ER stress signaling pathways that are activated in the hypoxic microenvironment of the tumors.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Chipurupalli, Sandhya UNSPECIFIED UNSPECIFIED UNSPECIFIED Kannan, Elango UNSPECIFIED UNSPECIFIED UNSPECIFIED Tergaonkar, Vinay UNSPECIFIED UNSPECIFIED UNSPECIFIED D'Andrea, Richard UNSPECIFIED UNSPECIFIED UNSPECIFIED Robinson, Nirmal UNSPECIFIED orcid.org/0000-0002-7361-9491 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-157167
DOI:	10.3390/ijms20030749
Journal or Publication Title:	Int. J. Mol. Sci.
Volume:	20
Number:	3
Date:	2019
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	1422-0067
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language UNFOLDED PROTEIN RESPONSE; ENDOPLASMIC-RETICULUM STRESS; INDUCIBLE FACTOR 1-ALPHA; TUMOR-CELL ADAPTATION; MESSENGER-RNA; HEPATOCELLULAR-CARCINOMA; TRANSLATIONAL CONTROL; DISULFIDE-ISOMERASE; SIGNALING PATHWAY; MAMMALIAN TARGET Multiple languages Biochemistry & Molecular Biology; Chemistry, Multidisciplinary Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15716