Universität zu Köln

Appel, Sarah, Grothe, Jon, Storck, Sarah, Janoschek, Ruth, Bae-Gartz, Inga, Wohlfarth, Maria, Handwerk, Marion, Hucklenbruch-Rother, Eva, Gellhaus, Alexandra and Doetsch, Joerg (2019). A Potential Role for GSK3 beta in Glucose-Driven Intrauterine Catch-Up Growth in Maternal Obesity. Endocrinology, 160 (2). S. 377 - 387. CARY: OXFORD UNIV PRESS INC. ISSN 1945-7170

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Abstract

Obesity and unhealthy nutrition are increasing and affect women of childbearing age and hence during pregnancy. Despite normal or even high birth weight, the offspring suffers from long-term metabolic risks. We hypothesized that fetal growth is disturbed during different intrauterine phases. Underlying molecular events remain elusive. Female mice were fed either a standard diet (SD) or a high-fat diet (HFD) after weaning until mating and during pregnancy. Pregnant mice were euthanized at gestational day (G) 15.5 and G18.5, and fetuses and placentas were removed for analysis. HFD fetuses displayed intrauterine growth restriction (IUGR) at G15.5, which disappeared until G18.5, indicating intrauterine catch-up growth during that time period. Main placental findings indicate decreased canonical Wnt-GSK3 beta signaling and lower proliferation rates at G18.5, which goes along with a smaller placental transfer zone. On the other hand, glucose depots (glycogen cluster) in HFD placentas decreased more strongly between G15.5 and G18.5 compared with placentas from SD mothers, and the glucose transporter protein GLUT-1 was increased at G18.5 in the HFD group. Maternal diet-induced obesity causes an IUGR phenotype at the beginning of the third week (G15.5) in our mouse model. This phenotype is reversed by the end of the third week (G18.5) despite a smaller placental transfer zone, probably based on GSK3 beta-mediated increased glucose mobilization in the placenta and hence an increased glucose supply to the fetus.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Appel, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Grothe, Jon UNSPECIFIED UNSPECIFIED UNSPECIFIED Storck, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Janoschek, Ruth UNSPECIFIED UNSPECIFIED UNSPECIFIED Bae-Gartz, Inga UNSPECIFIED UNSPECIFIED UNSPECIFIED Wohlfarth, Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Handwerk, Marion UNSPECIFIED UNSPECIFIED UNSPECIFIED Hucklenbruch-Rother, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Gellhaus, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Doetsch, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-157555
DOI:	10.1210/en.2018-00899
Journal or Publication Title:	Endocrinology
Volume:	160
Number:	2
Page Range:	S. 377 - 387
Date:	2019
Publisher:	OXFORD UNIV PRESS INC
Place of Publication:	CARY
ISSN:	1945-7170
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PLACENTAL GLYCOGEN-METABOLISM; CELLS; DIET Multiple languages Endocrinology & Metabolism Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15755