Universität zu Köln

Kohl, Joshua B., Mellis, Anna-Theresa and Schwarz, Guenter ORCID: 0000-0002-2118-9338 (2019). Homeostatic impact of sulfite and hydrogen sulfide on cysteine catabolism. Br. J. Pharmacol., 176 (4). S. 554 - 571. HOBOKEN: WILEY. ISSN 1476-5381

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Abstract

Cysteine is one of the two key sulfur-containing amino acids with important functions in redox homeostasis, protein functionality and metabolism. Cysteine is taken up by mammals via their diet and can also be derived from methionine via the transsulfuration pathway. The cellular concentration of cysteine is kept within a narrow range by controlling its synthesis and degradation. There are two pathways for the catabolism of cysteine leading to sulfate, taurine and thiosulfate as terminal products. The oxidative pathway produces taurine and sulfate, while the H2S pathway involves different enzymatic reactions leading to the formation and clearance of H2S, an important signalling molecule in mammals, resulting in thiosulfate and sulfate. Sulfite is a common intermediate in both catabolic pathways. Sulfite is considered as cytotoxic and produces neurotoxic S-sulfonates. As a result, a deficiency in the terminal steps of cysteine or H2S catabolism leads to severe forms of encephalopathy with the accumulation of sulfite and H2S in the body. This review links the homeostatic regulation of both cysteine catabolic pathways to sulfite and H2S. Linked Articles This article is part of a themed section on Chemical Biology of Reactive Sulfur Species. To view the other articles in this section visit

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kohl, Joshua B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mellis, Anna-Theresa UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwarz, Guenter UNSPECIFIED orcid.org/0000-0002-2118-9338 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-158135
DOI:	10.1111/bph.14464
Journal or Publication Title:	Br. J. Pharmacol.
Volume:	176
Number:	4
Page Range:	S. 554 - 571
Date:	2019
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1476-5381
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Biochemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CYSTATHIONINE BETA-SYNTHASE; MOLYBDENUM COFACTOR DEFICIENCY; SULFUR AMINO-ACIDS; GAMMA-LYASE; RAT-LIVER; HOMOCYSTEINE METABOLISM; OXIDASE DEFICIENCY; REDOX HOMEOSTASIS; CONCISE GUIDE; MICE Multiple languages Pharmacology & Pharmacy Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15813