Universität zu Köln

Engelmann, Ulrich M. ORCID: 0000-0001-9250-1686, Seifert, Julian, Mues, Benedikt ORCID: 0000-0002-3697-5032, Roitsch, Stefan, Menager, Christine ORCID: 0000-0002-4080-3508, Schmidt, Annette M. and Slabu, Ioana ORCID: 0000-0002-8945-4310 (2019). Heating efficiency of magnetic nanoparticles decreases with gradual immobilization in hydrogels. J. Magn. Magn. Mater., 471. S. 486 - 495. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1873-4766

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Abstract

Magnetic nanoparticles (MNP) applied in magnetic fluid hyperthermia cancer treatment interact with cancerous tissue in various ways. The impact of these interactions on MNP heating efficiency is hard to quantify and strongly depends on the MNP mobility inside the cancerous environment. There, this MNP mobility is inhibited by cell attachment and internalization. In this study, we model this impact and analyze the MNP heating under gradual immobilization of MNP in acrylamide hydrogels with tailored mesh size. Our results confirm a clear particle heating dependency on the state of immobilization of MNP. This state is related to the mean mesh size of the respective hydrogel. From this, the contributions of Brownian and Ned relaxation mechanisms to the overall particle heating are estimated. In fact, the heating efficiency decreases by up to 35% for the highest immobilization state of MNP. This result is discussed in the context of the field-dependent Brownian and Neel relaxation time, showing that the former significantly contributes to the heating efficiency even for small particles under the field parameters employed in this study.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Engelmann, Ulrich M. UNSPECIFIED orcid.org/0000-0001-9250-1686 UNSPECIFIED Seifert, Julian UNSPECIFIED UNSPECIFIED UNSPECIFIED Mues, Benedikt UNSPECIFIED orcid.org/0000-0002-3697-5032 UNSPECIFIED Roitsch, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Menager, Christine UNSPECIFIED orcid.org/0000-0002-4080-3508 UNSPECIFIED Schmidt, Annette M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Slabu, Ioana UNSPECIFIED orcid.org/0000-0002-8945-4310 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-158670
DOI:	10.1016/j.jmmm.2018.09.113
Journal or Publication Title:	J. Magn. Magn. Mater.
Volume:	471
Page Range:	S. 486 - 495
Date:	2019
Publisher:	ELSEVIER SCIENCE BV
Place of Publication:	AMSTERDAM
ISSN:	1873-4766
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HYPERTHERMIA; POLYACRYLAMIDE; TEMPERATURE; CANCER; CHEMOTHERAPY; RELAXATION; VISCOSITY; LIQUIDS; CELLS Multiple languages Materials Science, Multidisciplinary; Physics, Condensed Matter Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15867