Universität zu Köln

Wolfsgruber, Steffen, Molinuevo, Jose Luis ORCID: 0000-0003-0485-6001, Wagner, Michael ORCID: 0000-0003-2589-6440, Teunissen, Charlotte E. ORCID: 0000-0002-4061-0837, Rami, Lorena ORCID: 0000-0002-7411-1921, Coll-Padros, Nina ORCID: 0000-0002-9282-6701, Bouwman, Femke H. ORCID: 0000-0002-0527-2270, Slot, Rosalinde E. R. ORCID: 0000-0002-5798-8916, Wesselman, Linda M. P. ORCID: 0000-0001-6758-4504, Peters, Oliver ORCID: 0000-0003-0568-2998, Luther, Katja ORCID: 0000-0002-3404-4680, Buerger, Katharina, Priller, Josef ORCID: 0000-0001-7596-0979, Laske, Christoph, Teipel, Stefan J. ORCID: 0000-0002-3586-3194, Spottke, Annika, Heneka, Michael T. ORCID: 0000-0003-4996-1630, Duezel, Emrah ORCID: 0000-0002-0139-5388, Drzezga, Alexander ORCID: 0000-0001-6018-716X, Wiltfang, Jens ORCID: 0000-0003-1492-5330, Sikkes, Sietske A. M. ORCID: 0000-0002-0161-3656, van der Flier, Wiesje M. ORCID: 0000-0001-8766-6224 and Jessen, Frank ORCID: 0000-0003-1067-2102 (2019). Prevalence of abnormal Alzheimer's disease biomarkers in patients with subjective cognitive decline: cross-sectional comparison of three European memory clinic samples. Alzheimers Res. Ther., 11. LONDON: BMC. ISSN 1758-9193

Full text not available from this repository.

Abstract

IntroductionSubjective cognitive decline (SCD) in cognitively unimpaired older individuals has been recognized as an early clinical at-risk state for Alzheimer's disease (AD) dementia and as a target population for future dementia prevention trials. Currently, however, SCD is heterogeneously defined across studies, potentially leading to variations in the prevalence of AD pathology. Here, we compared the prevalence and identified common determinants of abnormal AD biomarkers in SCD across three European memory clinics participating in the European initiative on harmonization of SCD in preclinical AD (Euro-SCD).MethodsWe included three memory clinic SCD samples with available cerebrospinal fluid (CSF) biomaterial (IDIBAPS, Barcelona, Spain, n=44; Amsterdam Dementia Cohort (ADC), The Netherlands, n=50; DELCODE multicenter study, Germany, n=42). CSF biomarkers (amyloid beta (A)42, tau, and phosphorylated tau (ptau181)) were centrally analyzed in Amsterdam using prespecified cutoffs to define prevalence of pathological biomarker concentrations. We used logistic regression analysis in the combined sample across the three centers to investigate center effects with regard to likelihood of biomarker abnormality while taking potential common predictors (e.g., age, sex, apolipoprotein E (APOE) status, subtle cognitive deficits, depressive symptoms) into account.ResultsThe prevalence of abnormal A42, but not tau or ptau181, levels was different across centers (64% DELCODE, 57% IDIBAPS, 22% ADC; p<0.001). Logistic regression analysis revealed that the likelihood of abnormal A42 (and also abnormal tau or ptau181) levels was predicted by age and APOE status. For A42 abnormality, we additionally observed a center effect, indicating between-center heterogeneity not explained by age, APOE, or the other included covariates.ConclusionsWhile heterogeneous frequency of abnormal A42 was partly explained by between-sample differences in age range and APOE status, the additional observation of center effects indicates between-center heterogeneity that may be attributed to different recruitment procedures. These findings highlight the need for the development of harmonized recruitment protocols for SCD case definition in multinational studies to achieve similar enrichment rates of preclinical AD.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wolfsgruber, Steffen UNSPECIFIED UNSPECIFIED UNSPECIFIED Molinuevo, Jose Luis UNSPECIFIED orcid.org/0000-0003-0485-6001 UNSPECIFIED Wagner, Michael UNSPECIFIED orcid.org/0000-0003-2589-6440 UNSPECIFIED Teunissen, Charlotte E. UNSPECIFIED orcid.org/0000-0002-4061-0837 UNSPECIFIED Rami, Lorena UNSPECIFIED orcid.org/0000-0002-7411-1921 UNSPECIFIED Coll-Padros, Nina UNSPECIFIED orcid.org/0000-0002-9282-6701 UNSPECIFIED Bouwman, Femke H. UNSPECIFIED orcid.org/0000-0002-0527-2270 UNSPECIFIED Slot, Rosalinde E. R. UNSPECIFIED orcid.org/0000-0002-5798-8916 UNSPECIFIED Wesselman, Linda M. P. UNSPECIFIED orcid.org/0000-0001-6758-4504 UNSPECIFIED Peters, Oliver UNSPECIFIED orcid.org/0000-0003-0568-2998 UNSPECIFIED Luther, Katja UNSPECIFIED orcid.org/0000-0002-3404-4680 UNSPECIFIED Buerger, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Priller, Josef UNSPECIFIED orcid.org/0000-0001-7596-0979 UNSPECIFIED Laske, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Teipel, Stefan J. UNSPECIFIED orcid.org/0000-0002-3586-3194 UNSPECIFIED Spottke, Annika UNSPECIFIED UNSPECIFIED UNSPECIFIED Heneka, Michael T. UNSPECIFIED orcid.org/0000-0003-4996-1630 UNSPECIFIED Duezel, Emrah UNSPECIFIED orcid.org/0000-0002-0139-5388 UNSPECIFIED Drzezga, Alexander UNSPECIFIED orcid.org/0000-0001-6018-716X UNSPECIFIED Wiltfang, Jens UNSPECIFIED orcid.org/0000-0003-1492-5330 UNSPECIFIED Sikkes, Sietske A. M. UNSPECIFIED orcid.org/0000-0002-0161-3656 UNSPECIFIED van der Flier, Wiesje M. UNSPECIFIED orcid.org/0000-0001-8766-6224 UNSPECIFIED Jessen, Frank UNSPECIFIED orcid.org/0000-0003-1067-2102 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-159126
DOI:	10.1186/s13195-018-0463-y
Journal or Publication Title:	Alzheimers Res. Ther.
Volume:	11
Date:	2019
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1758-9193
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Sonstiges > Zentrum für Versorgungsforschung Köln
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language CEREBROSPINAL-FLUID BIOMARKERS; OLDER-ADULTS; IMPAIRMENT; VALIDATION; PREVENTION; FRAMEWORK; TRIALS; RISK; CARE Multiple languages Clinical Neurology; Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15912