Nieroda, Lech, Maas, Lukas, Thiebes, Scott, Lang, Ulrich ORCID: 0000-0001-7166-0805, Sunyaev, Ali, Achter, Viktor and Peifer, Martin
(2019).
iRODS metadata management for a cancer genome analysis workflow.
BMC Bioinformatics, 20.
LONDON:
BMC.
ISSN 1471-2105
Abstract
BackgroundThe massive amounts of data from next generation sequencing (NGS) methods pose various challenges with respect to data security, storage and metadata management. While there is a broad range of data analysis pipelines, these challenges remain largely unaddressed to date.ResultsWe describe the integration of the open-source metadata management system iRODS (Integrated Rule-Oriented Data System) with a cancer genome analysis pipeline in a high performance computing environment. The system allows for customized metadata attributes as well as fine-grained protection rules and is augmented by a user-friendly front-end for metadata input. This results in a robust, efficient end-to-end workflow under consideration of data security, central storage and unified metadata information.ConclusionsIntegrating iRODS with an NGS data analysis pipeline is a suitable method for addressing the challenges of data security, storage and metadata management in NGS environments.
Item Type: | Journal Article | ||||||||||||||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-159179 | ||||||||||||||||||||||||||||||||
DOI: | 10.1186/s12859-018-2576-5 | ||||||||||||||||||||||||||||||||
Journal or Publication Title: | BMC Bioinformatics | ||||||||||||||||||||||||||||||||
Volume: | 20 | ||||||||||||||||||||||||||||||||
Date: | 2019 | ||||||||||||||||||||||||||||||||
Publisher: | BMC | ||||||||||||||||||||||||||||||||
Place of Publication: | LONDON | ||||||||||||||||||||||||||||||||
ISSN: | 1471-2105 | ||||||||||||||||||||||||||||||||
Language: | English | ||||||||||||||||||||||||||||||||
Faculty: | Faculty of Mathematics and Natural Sciences | ||||||||||||||||||||||||||||||||
Divisions: | Faculty of Mathematics and Natural Sciences > Department of Mathematics and Computer Science > Institute of Computer Science | ||||||||||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||||||||||
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Refereed: | Yes | ||||||||||||||||||||||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/15917 |
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