Universität zu Köln

Seewald, Stephan, Obermaier, Manuel ORCID: 0000-0003-0881-4757, Lefering, Rolf, Bohn, Andreas, Georgieff, Michael, Muth, Claus-Martin, Graesner, Jan-Thorsten, Masterson, Siobhan ORCID: 0000-0002-3003-4792, Scholz, Jens and Wnent, Jan (2019). Application of mechanical cardiopulmonary resuscitation devices and their value in out-of-hospital cardiac arrest: A retrospective analysis of the German Resuscitation Registry. PLoS One, 14 (1). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Background Cardiac arrest is an event with a limited prognosis which has not substantially changed since the first description of cardiopulmonary resuscitation (CPR) in 1960. A promising new treatment approach may be mechanical CPR devices (mechanical CPR). Methods In a retrospective analysis of the German Resuscitation Registry between 2007-2014, we examined the outcome after using mechanical CPR on return of spontaneous circulation (ROSC) in adults with out-of-hospital cardiac arrest (OHCA). We compared mechanical CPR to manual CPR. According to preclinical risk factors, we calculated the predicted ROSC-after-cardiac-arrest (RACA) score for each group and compared it to the rate of ROSC observed. Using multivariate analysis, we adjusted the influence of the devices' application on ROSC for epidemiological factors and therapeutic measures. Results We included 19,609 patients in the study. ROSC was achieved in 51.5% of the mechanical CPR group (95%-CI 48.2-54.8%, ROSC expected 42.5%) and in 41.2% in the manual CPR group (95%-CI 40.4-41.9%, ROSC expected 39.2%). After multivariate adjustment, mechanical CPR was found to be an independent predictor of ROSC (OR 1.77; 95%-CI 1.48-2.12). Duration of CPR is a key determinant for achieving ROSC. Conclusions Mechanical CPR was associated with an increased rate of ROSC and when adjusted for risk factors appeared advantageous over manual CPR. Mechanical CPR devices may increase survival and should be considered in particular circumstances according to a physicians' decision, especially during prolonged resuscitation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Seewald, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Obermaier, Manuel UNSPECIFIED orcid.org/0000-0003-0881-4757 UNSPECIFIED Lefering, Rolf UNSPECIFIED UNSPECIFIED UNSPECIFIED Bohn, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Georgieff, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Muth, Claus-Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Graesner, Jan-Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Masterson, Siobhan UNSPECIFIED orcid.org/0000-0002-3003-4792 UNSPECIFIED Scholz, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Wnent, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-159660
DOI:	10.1371/journal.pone.0208113
Journal or Publication Title:	PLoS One
Volume:	14
Number:	1
Date:	2019
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MANUAL CHEST COMPRESSION; DEFIBRILLATION; INTERRUPTIONS; SURVIVAL; QUALITY; SCORE; CPR Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15966