Kalbe, Elke, Roheger, Mandy ORCID: 0000-0002-6015-3194, Paluszak, Kay, Meyer, Julia, Becker, Jutta, Fink, Gereon R., Kukolja, Juraj, Rahn, Andreas, Szabados, Florian, Wirth, Brunhilde and Kessler, Josef (2018). Effects of a Cognitive Training With and Without Additional Physical Activity in Healthy Older Adults: A Follow-Up 1 Year After a Randomized Controlled Trial. Front. Aging Neurosci., 10. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1663-4365

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Abstract

Background: Combining cognitive training (CT) with physical activity (CPT) has been suggested to be most effective in maintaining cognition in healthy older adults, but data are scarce and inconsistent regarding long-term effects (follow-up; FU) and predictors of success. Objective: To investigate the 1-year FU effects of CPT versus CT and CPT plus counseling (CPT+C), and to identify predictors for CPT success at FU. Setting and Participants: We included 55 healthy older participants in the data analyses; 18 participants (CPT group) were used for the predictor analysis. Interventions: In a randomized controlled trial, participants conducted a CT, CPT, or CPT+C for 7 weeks. Outcome Measures: Overall cognition, verbal, figural, and working memory, verbal fluency, attention, planning, and visuo-construction. Results: While within-group comparisons showed cognitive improvements for all types of training, only one significant interaction Group x Time favoring CPT in comparison to CPT+C was found for overall cognition and verbal long-term memory. The most consistent predictor for CPT success (in verbal short-term memory, verbal fluency, attention) was an initial low baseline performance. Lower education predicted working memory gains. Higher levels of insulin-like growth factor 1 (IGF-1) and lower levels of brain-derived neurotrophic factor at baseline (BDNF) predicted alternating letter verbal fluency gains. Discussion: Within-group comparisons indicate that all used training types are helpful to maintain cognition. The fact that cognitive and sociodemographic data as well as nerve growth factors predict long-term benefits of CPT contributes to the understanding of the mechanisms underlying training success and may ultimately help to adapt training to individual profiles.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Kalbe, ElkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roheger, MandyUNSPECIFIEDorcid.org/0000-0002-6015-3194UNSPECIFIED
Paluszak, KayUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meyer, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Becker, JuttaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fink, Gereon R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kukolja, JurajUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rahn, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Szabados, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wirth, BrunhildeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kessler, JosefUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-161888
DOI: 10.3389/fnagi.2018.00407
Journal or Publication Title: Front. Aging Neurosci.
Volume: 10
Date: 2018
Publisher: FRONTIERS MEDIA SA
Place of Publication: LAUSANNE
ISSN: 1663-4365
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
INDIVIDUAL-DIFFERENCES; NEUROTROPHIC FACTOR; PARKINSONS-DISEASE; MEDITERRANEAN DIET; MENTAL ACTIVITY; AGING BRAIN; EXERCISE; BDNF; GROWTH; TERMMultiple languages
Geriatrics & Gerontology; NeurosciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/16188

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