Universität zu Köln

Sengler, Claudia, Zink, Julian, Klotsche, Jens, Niewerth, Martina, Liedmann, Ina, Horneff, Gerd, Kessel, Christoph ORCID: 0000-0002-0638-2949, Ganser, Gerd, Thon, Angelika, Haas, Johannes-Peter, Hospach, Anton, Weller-Heinemann, Frank, Heiligenhaus, Arnd, Foell, Dirk, Zink, Angela and Minden, Kirsten (2018). Vitamin D deficiency is associated with higher disease activity and the risk for uveitis in juvenile idiopathic arthritis - data from a German inception cohort. Arthritis Res. Ther., 20. LONDON: BMC. ISSN 1478-6362

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Abstract

ObjectiveThe objective was to evaluate the 25(OH) vitamin D (25(OH)D) status of patients with juvenile idiopathic arthritis (JIA) and determine whether the 25(OH)D level is associated with disease activity and the course of JIA.MethodsPatients 16years of age with recently diagnosed JIA (<12months) were enrolled in the inception cohort of patients with newly diagnosed JIA (ICON), an ongoing prospective observational, controlled multicenter study started in 2010. Clinical and laboratory parameters were ascertained quarterly during the first year and half-yearly thereafter.Of the 954 enrolled patients, 360 patients with two blood samples taken during the first 2years after inclusion and with follow up of 3years were selected. The serum 25(OH)D levels were determined and compared with those of subjects from the general population after matching for age, sex, migration status and the month of blood-drawing.ResultsNearly half of the patients had a deficient 25(OH)D level (<20ng/ml) in the first serum sample and a quarter had a deficient level in both samples. Disease activity and the risk of developing JIA-associated uveitis were inversely correlated with the 25(OH)D level (=-0.20, 95% CI -0.37; 0.03, hazard ratio 0.95, 95% CI 0.91; 0.99, respectively).ConclusionIn this study, 25(OH)D deficiency was common and associated with higher disease activity and risk of developing JIA-associated uveitis. Further studies are needed to substantiate these results and determine whether correcting 25(OH)D deficiency is beneficial in JIA.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sengler, Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Zink, Julian UNSPECIFIED UNSPECIFIED UNSPECIFIED Klotsche, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Niewerth, Martina UNSPECIFIED UNSPECIFIED UNSPECIFIED Liedmann, Ina UNSPECIFIED UNSPECIFIED UNSPECIFIED Horneff, Gerd UNSPECIFIED UNSPECIFIED UNSPECIFIED Kessel, Christoph UNSPECIFIED orcid.org/0000-0002-0638-2949 UNSPECIFIED Ganser, Gerd UNSPECIFIED UNSPECIFIED UNSPECIFIED Thon, Angelika UNSPECIFIED UNSPECIFIED UNSPECIFIED Haas, Johannes-Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Hospach, Anton UNSPECIFIED UNSPECIFIED UNSPECIFIED Weller-Heinemann, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Heiligenhaus, Arnd UNSPECIFIED UNSPECIFIED UNSPECIFIED Foell, Dirk UNSPECIFIED UNSPECIFIED UNSPECIFIED Zink, Angela UNSPECIFIED UNSPECIFIED UNSPECIFIED Minden, Kirsten UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-162079
DOI:	10.1186/s13075-018-1765-y
Journal or Publication Title:	Arthritis Res. Ther.
Volume:	20
Date:	2018
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1478-6362
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language 25-HYDROXYVITAMIN D LEVELS; RHEUMATOID-ARTHRITIS; CHILDREN; PREVALENCE; ADOLESCENTS; PREVENTION; METABOLISM Multiple languages Rheumatology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16207