Universität zu Köln

Hammes, Jochen, van Heek, Lutz, Hohberg, Melanie, Reifegerst, Manuel, Stockter, Simone, Dietlein, Markus, Wild, Markus, Drzezga, Alexander, Schmidt, Matthias and Kobe, Carsten (2018). Impact of different approaches to calculation of treatment activities on achieved doses in radioiodine therapy of benign thyroid diseases. EJNMMI Phys., 5. LONDON: SPRINGEROPEN. ISSN 2197-7364

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Abstract

PurposeRadioiodine has been used for the treatment of benign thyroid diseases for over 70years. However, internationally, there is no common standard for pretherapeutic dosimetry to optimally define the individual therapy activity. Here, we analyze how absorbed tissue doses are influenced by different approaches to pretherapeutic activity calculation of varying complexity.MethodsPretherapeutic determination of treatment activity was retrospectively recalculated in 666 patients who had undergone radioiodine therapy for benign thyroid diseases (Graves' disease, non-toxic goiter, and uni- and multinodular goiter). Approaches considering none, some, or all of a set of individual factors, including target volume, maximum radioiodine uptake, and effective half-life, were applied. Assuming individually stable radioiodine kinetics, which had been monitored twice a day under therapy, hypothetically achieved tissue doses based on hypothetically administered activities resulting from the different methods of activity calculation were compared to intended target doses.ResultsThe Marinelli formula yields the smallest deviations of hypothetically achieved doses from intended target doses. Approaches taking individual target volume into consideration perform better than fixed therapy activities, which lead to high variances in achieved doses and high deviations of hypothetically achieved doses from intended target doses.ConclusionElaborate pretherapeutic dose planning, taking individual radioiodine uptake, half-life, and target volume into consideration, should be used whenever possible. The use of disease-specific fixed activities cannot be recommended. Deviations of achieved tissue doses from target doses can already be significantly lowered by application of volume-adapted treatment activities if more elaborate means are not available.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hammes, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED van Heek, Lutz UNSPECIFIED UNSPECIFIED UNSPECIFIED Hohberg, Melanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Reifegerst, Manuel UNSPECIFIED UNSPECIFIED UNSPECIFIED Stockter, Simone UNSPECIFIED UNSPECIFIED UNSPECIFIED Dietlein, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Wild, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Kobe, Carsten UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-162173
DOI:	10.1186/s40658-018-0231-x
Journal or Publication Title:	EJNMMI Phys.
Volume:	5
Date:	2018
Publisher:	SPRINGEROPEN
Place of Publication:	LONDON
ISSN:	2197-7364
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BORDERLINE HYPERTHYROID PATIENTS; GRAVES-DISEASE; FOLLOW-UP; I-131; TC-99M-PERTECHNETATE; HYPOTHYROIDISM; DOSIMETRY; SELECTION; STANDARD; VOLUME Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16217