Universität zu Köln

Willkommen, Desiree, Lucio, Marianna ORCID: 0000-0002-5844-0098, Moritz, Franco, Forcisi, Sara, Kanawati, Basem, Smirnov, Kirill S., Schroeter, Michael, Sigaroudi, Ali ORCID: 0000-0002-3176-4631, Schmitt-Kopplin, Philippe ORCID: 0000-0003-0824-2664 and Michalke, Bernhard (2018). Metabolomic investigations in cerebrospinal fluid of Parkinson's disease. PLoS One, 13 (12). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

The underlying mechanisms of Parkinson's disease are not completely revealed. Especially, early diagnostic biomarkers are lacking. To characterize early pathophysiological events, research is focusing on metabolomics. In this case-control study we investigated the metabolic profile of 31 Parkinson's disease-patients in comparison to 95 neurologically healthy controls. The investigation of metabolites in CSF was performed by a 12 Tesla SolariX Fourier transform-ion cyclotron resonance-mass spectrometer (FT-ICR-MS). Multivariate statistical analysis sorted the most important biomarkers in relation to their ability to differentiate Parkinson versus control. The affected metabolites, their connection and their conversion pathways are described by means of network analysis. The metabolic profiling by FT-ICR-MS in CSF yielded in a good group separation, giving insights into the disease mechanisms. A total number of 243 metabolites showed an affected intensity in Parkinson's disease, whereas 15 of these metabolites seem to be the main biological contributors. The network analysis showed a connection to the tricarboxylic cycle (TCA cycle) and therefore to mitochondrial dysfunction and increased oxidative stress within mitochondria. The metabolomic analysis of CSF in Parkinson's disease showed an association to pathways which are involved in lipid/ fatty acid metabolism, energy metabolism, glutathione metabolism and mitochondrial dysfunction.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Willkommen, Desiree UNSPECIFIED UNSPECIFIED UNSPECIFIED Lucio, Marianna UNSPECIFIED orcid.org/0000-0002-5844-0098 UNSPECIFIED Moritz, Franco UNSPECIFIED UNSPECIFIED UNSPECIFIED Forcisi, Sara UNSPECIFIED UNSPECIFIED UNSPECIFIED Kanawati, Basem UNSPECIFIED UNSPECIFIED UNSPECIFIED Smirnov, Kirill S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schroeter, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Sigaroudi, Ali UNSPECIFIED orcid.org/0000-0002-3176-4631 UNSPECIFIED Schmitt-Kopplin, Philippe UNSPECIFIED orcid.org/0000-0003-0824-2664 UNSPECIFIED Michalke, Bernhard UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-162303
DOI:	10.1371/journal.pone.0208752
Journal or Publication Title:	PLoS One
Volume:	13
Number:	12
Date:	2018
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POLYUNSATURATED FATTY-ACIDS; ARACHIDONIC-ACID; BRAIN; GLUTATHIONE; BIOMARKERS; PLASMA; MITOCHONDRIAL; GENDER; METABOLITES; DYSFUNCTION Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16230