Universität zu Köln

Helbig, Doris, Mauch, Cornelia, Buettner, Reinhard and Quaas, Alexander (2018). Immunohistochemical expression of melanocytic and myofibroblastic markers and their molecular correlation in atypical fibroxanthomas and pleomorphic dermal sarcomas. J. Cutan. Pathol., 45 (12). S. 880 - 886. HOBOKEN: WILEY. ISSN 1600-0560

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Abstract

Background Methods Atypical fibroxanthomas (AFXs) and pleomorphic dermal sarcomas (PDSs) are UV-induced pleomorphic skin tumors with a non-specific immunoprofile. For that reason, exclusion of other dedifferentiated tumor entities by immunohistochemistry is still mandatory to avoid misdiagnosis. We determined the expression frequency of several melanocytic and myofibroblastic markers investigating 50 AFXs and PDSs.. Next-generation-sequencing (NGS) was performed in microphthalmia-associated transcription factor (MiTF)-expressing cases. Results Conclusion We identified one MiTF-expressing AFX and PDS, and two PDSs harboring single S100-positive dendritic cells whereas Melan A, HMB45, and SOX10 were negative. Calponin was moderately expressed by tumor giant cells in one PDS whereas h-caldesmon, desmin, and myogenin were not expressed in any of the AFXs or PDSs. The MiTF-positive AFX presented CDKN2A, OXA1L, and PDGFRA mutations whereas the PDS harbored a typical TP53 mutation. Both patients have not shown any tumor progression over the last 16 and 30 months. Rarely, AFX and PDS express the melanocytic marker MiTF and/or the myofibroblastic marker calponin. In doubtful cases, using a panel of immunohistochemical markers helps to avoid misdiagnosis.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Helbig, Doris UNSPECIFIED UNSPECIFIED UNSPECIFIED Mauch, Cornelia UNSPECIFIED UNSPECIFIED UNSPECIFIED Buettner, Reinhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Quaas, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-163968
DOI:	10.1111/cup.13346
Journal or Publication Title:	J. Cutan. Pathol.
Volume:	45
Number:	12
Page Range:	S. 880 - 886
Date:	2018
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1600-0560
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MICROPHTHALMIA TRANSCRIPTION FACTOR; MALIGNANT FIBROUS HISTIOCYTOMA; USEFUL DIAGNOSTIC MARKER; SQUAMOUS-CELL CARCINOMA; SMOOTH-MUSCLE; H-CALDESMON; DESMOPLASTIC MELANOMA; DIFFERENTIAL-DIAGNOSIS; CD99 IMMUNOREACTIVITY; TUMORS Multiple languages Dermatology; Pathology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16396