Universität zu Köln

Wagner, S., Reder, H., Sharma, S. J., Wuerdemann, N., Wittekindt, C. and Klussmann, J. P. (2018). HPV-associated oropharyngeal cancer-incidence, trends, diagnosis, and treatment. Urologe, 57 (12). S. 1457 - 1464. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-0563

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Abstract

A rising incidence of oropharyngeal squamous cell carcinoma (OPSCC) is reported by many countries worldwide and OPSCC associated with human papillomavirus (HPV) has been recently defined as a new class of head and neck cancers. Besides tobacco and alcohol consumption, HPV is an accepted risk and prognostic factor for OPSCC. Although the incidence increase of HPV-associated OPSCC is convincing, cancer registry studies and studies based on cohorts often have drawbacks regarding data linkage to comparable experimental data, comparable anatomical definitions or HPV diagnostics. Patients with HPV-associated OPSCC have remarkably better prognosis and the tumors differ from HPV-negative OPSCC with respect to molecular and genetic aspects. Nevertheless, choice of therapy is independent of HPV, and rather is subject to the individual patient's condition, local preference and anatomic characteristics. New concepts emerge in immune-checkpoint oncology, which might be a valuable add-on to established concepts. Also, treatment de-escalation (e.g., by reduction of radiation dosage) might be suitable for patients with certain risk profiles. Prophylactic vaccination can contribute to reducing HPV-induced disease, likewise OPSCC. Prerequisite is a high rate of vaccination, which is currently not sufficient in Germany. Because of currently low vaccination rates and the rather long time between initial infection and HPV-induced carcinogenesis, reduction of incidence increase or prevalence of HPV-associated OPSCC is not expected in the near future.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wagner, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Reder, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sharma, S. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wuerdemann, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wittekindt, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klussmann, J. P. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-164440
DOI:	10.1007/s00120-018-0810-4
Journal or Publication Title:	Urologe
Volume:	57
Number:	12
Page Range:	S. 1457 - 1464
Date:	2018
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-0563
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SQUAMOUS-CELL CARCINOMA; HUMAN-PAPILLOMAVIRUS; NECK CANCERS; VIRAL LOAD; HEAD; P16(INK4A); EXPRESSION; DNA; INTEGRATION; SITES Multiple languages Urology & Nephrology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16444