Universität zu Köln

Ghanem, A., Liebetrau, C., Diener, H. -C., Elsaesser, A., Grau, A., Groeschel, K., Mattle, H., Massberg, S., Moellmann, H., Nef, H., Sander, D., Weimar, C., Woehrle, J. and Baldus, S. (2018). Interventional PFO closure. Consensus document of the German Workgroup of Interventional Cardiology (AGIK) of the German Cardiac Society (DGK) in cooperation with the German Society of Neurology (DGN) and the German Stroke Foundation (DSG). Kardiologe, 12 (6). S. 415 - 424. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1864-9726

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Abstract

Almost every second patient with cryptogenic stroke has apatent foramen ovale (PFO). This consensus document firstly provides an evidence-based overview on the diagnostics of PFO, current studies, interventional closure, and medical therapy in terms of platelet aggregation inhibitors and anticoagulation. Secondly, the risk-benefit balance of interventional versus antithrombotic therapy with and without oral anticoagulants in patients with cryptogenic stroke and PFO is discussed based on recent findings of randomized controlled clinical trials (RCTs) and meta-analyses. Ultimately, the consented recommendations and levels thereof are indicated. The published data demonstrate the superiority of interventional PFO closure. There is asignificant reduction of recurrent strokes in patients with an interventional PFO closure device compared to medical therapy. The complication rate of the interventional therapy is low and particularly younger patients with cryptogenic stroke benefit from interventional PFO closure. In summary, interventional PFO closure is superior to medical treatment in patients with cryptogenic stroke aged <60years.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ghanem, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Liebetrau, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Diener, H. -C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Elsaesser, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Grau, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Groeschel, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mattle, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Massberg, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Moellmann, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nef, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sander, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Weimar, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Woehrle, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Baldus, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-164645
DOI:	10.1007/s12181-018-0277-y
Journal or Publication Title:	Kardiologe
Volume:	12
Number:	6
Page Range:	S. 415 - 424
Date:	2018
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1864-9726
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PATENT FORAMEN OVALE; CRYPTOGENIC STROKE; MEDICAL THERAPY; ANTIPLATELET THERAPY; PERCUTANEOUS CLOSURE; DEVICE CLOSURE; PREVENTION Multiple languages Cardiac & Cardiovascular Systems Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16464