Rohner, Eliane, Butikofer, Lukas, Schmidlin, Kurt, Sengayi, Mazvita, Maskew, Mhairi, Giddy, Janet, Moore, Richard D., Goedert, James J., Gill, M. John, Silverberg, Michael J., Patel, Pragna, Castilho, Jessica, Hoy, Jennifer, Sohn, Annette, Bani-Sadr, Firouze, Taylor, Ninon, Paparizos, Vassilios, Le Moing, Vincent, Bonnet, Fabrice, Verbon, Annelies, Vehreschild, Jorg Janne, Post, Frank A., Sabin, Caroline, Mocroft, Amanda, Dronda, Fernando, Obel, Niels, Grabar, Sophie, Spagnuolo, Vincenzo, Antinori, Andrea, Quiros-Rol-dan, Eugenia, Mussini, Cristina, Miro, Jose M., Meyer, Laurence, Hasse, Barbara, Konopnicki, Deborah, Roca, Bernardino, Boue, Francois, Barger, Diana, Raben, Dorthe, Clifford, Gary M., Franceschi, Silvia, Brockmeyer, Norbert, Egger, Matthias and Bohlius, Julia (2018). Non-Hodgkin lymphoma risk in adults living with HIV across five continents The AIDS-defining Cancer Project Working Group of leDEA and COHERE in EuroCoord. Aids, 32 (18). S. 2777 - 2787. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1473-5571

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Abstract

Objective: To compare non-I lodgkin lymphoma (NHL) incidence rates in adults who started antiretroviral therapy (ART) across the Asia-Pacific, South Africa, Europe, Latin, and North America. Methods: We included cohort data of adults living with HIV who started ART after 1995 within the framework of the International epidemiology Databases to Evaluate AIDS (leDEA) and (he Collaboration of Observational HIV Epidemiological Research in Europe (COHERE). We used flexible parametric survival models to compare regional NHL rates at 2 years after ART start and to identify risk factors for NHL. Results: We included 210898 adults with 1.1 million person-years (pys) of follow-up and 1552 incident NHL cases (raw overall incidence rate 142/100000 pys). After adjusting for age at ART start, first-line ART regimen, calendar period of ART start, and especially current CD4(+) cell count, NHL rates were similar across regions for most population groups. However, South African women remained at increased risk of developing NHL compared with their European counterparts [adjusted hazard ratio [aHR] 1.79, 95% CI 1.19-2.701. In Europe, Latin, and North America, NHL risk was highest in MSM (aHR 1.30, 95% CI 1.14-1.48), followed by heterosexual men (referent), and women (aHR 0.66, 95% CI 0.57-0.78). Conclusion: The risk of developing NHL is higher in women in South Africa than in Europe and higher in MSM compared with heterosexual men and women. Reasons for these differences remain unclear. Early ART access and regular patient monitoring to avert low CD4(+) cell counts remain key for NHL prevention. copyright (C) 2018 WolLers Kluwer Health, Inc. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Rohner, ElianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Butikofer, LukasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidlin, KurtUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sengayi, MazvitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maskew, MhairiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Giddy, JanetUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moore, Richard D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goedert, James J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gill, M. JohnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Silverberg, Michael J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Patel, PragnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Castilho, JessicaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoy, JenniferUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sohn, AnnetteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bani-Sadr, FirouzeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Taylor, NinonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paparizos, VassiliosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Le Moing, VincentUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bonnet, FabriceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Verbon, AnneliesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vehreschild, Jorg JanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Post, Frank A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sabin, CarolineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mocroft, AmandaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dronda, FernandoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Obel, NielsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grabar, SophieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spagnuolo, VincenzoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antinori, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Quiros-Rol-dan, EugeniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mussini, CristinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Miro, Jose M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meyer, LaurenceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hasse, BarbaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Konopnicki, DeborahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roca, BernardinoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boue, FrancoisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barger, DianaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Raben, DortheUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Clifford, Gary M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Franceschi, SilviaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brockmeyer, NorbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Egger, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bohlius, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-165293
DOI: 10.1097/QAD.0000000000002003
Journal or Publication Title: Aids
Volume: 32
Number: 18
Page Range: S. 2777 - 2787
Date: 2018
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Place of Publication: PHILADELPHIA
ISSN: 1473-5571
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ANTIRETROVIRAL THERAPY; IMMUNE RECONSTITUTION; KAPOSI-SARCOMA; IMMUNODEFICIENCY; INFECTION; ERA; EPIDEMIOLOGY; TUBERCULOSIS; COINFECTION; HIV/AIDSMultiple languages
Immunology; Infectious Diseases; VirologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/16529

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