Laut, Kamilla Gronborg, Shepherd, Leah, Gottfredsson, Magnus ORCID: 0000-0003-2465-0422, Sedlacek, Dalibor ORCID: 0000-0003-4711-6679, Knysz, Brygida, Begovac, Josip, Radoi, Roxana, Schmied, Brigitte, Chkhartishvili, Nikoloz ORCID: 0000-0002-1309-825X, Florence, Eric ORCID: 0000-0002-7004-9120, Ristola, Matti ORCID: 0000-0001-5115-2811, Faetkenheuer, Gerd, Mulcahy, Fiona, Schmid, Patrick, Kuzovatova, Elena, Paduta, Dzmitry, Smidt, Jelena, Domingo, Pere, Szlavik, Janos, Lundgren, Jens, Mocroft, Amanda and Kirk, Ole (2018). Variation in antiretroviral treatment coverage and virological suppression among three HIV key populations. Aids, 32 (18). S. 2807 - 2820. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1473-5571

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Abstract

Objectives: We assessed differences in antiretroviral treatment (ART) coverage and virological suppression across three HIV key populations, as defined by self-reported HIV transmission category: sex between men, injection drug use (IDU) and heterosexual transmission. Design: A multinational cohort study. Methods: Within the EuroSIDA study, we assessed region-specific percentages of ART coverage among those in care and virological suppression (<500 copies/ml) among those on ART, and analysed differences between transmission categories using logistic regression. Results: Among 12 872 participants followed from 1 July 2014 to 30 June 2016, the percentages of ART-coverage and virological suppression varied between transmission categories, depending on geographical region (global P for interaction: P = 0.0148 for ART-coverage, P = 0.0006 for virological suppression). In Western [adjusted odds ratio (aOR) 1.41 (95% confidence interval 1.14-1.75)] and Northern Europe [aOR 1.68 (95% confidence interval 1.25-2.26)], heterosexuals were more likely to receive ART than MSM, while in Eastern Europe, there was some evidence that infection through IDU [aOR 0.60 (95% confidence interval 0.31-1.14)] or heterosexual contact [aOR 0.58 (95% confidence interval 0.30-1.10)] was associated with lower odds of receiving ART. In terms of virological suppression, people infected through IDU or heterosexual contact in East Central and Eastern Europe were around half as likely as MSM to have a suppressed viral load on ART, while we observed no differences in virological suppression across transmission categories in Western and Northern Europe. Conclusion: In our cohort, patterns of ART-coverage and virological suppression among key populations varied by geographical region, emphasizing the importance of tailoring HIV programmes to the local epidemic. Copyright (C) 2018 Wolters Kluwer Health, Inc. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Laut, Kamilla GronborgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shepherd, LeahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gottfredsson, MagnusUNSPECIFIEDorcid.org/0000-0003-2465-0422UNSPECIFIED
Sedlacek, DaliborUNSPECIFIEDorcid.org/0000-0003-4711-6679UNSPECIFIED
Knysz, BrygidaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Begovac, JosipUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Radoi, RoxanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmied, BrigitteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chkhartishvili, NikolozUNSPECIFIEDorcid.org/0000-0002-1309-825XUNSPECIFIED
Florence, EricUNSPECIFIEDorcid.org/0000-0002-7004-9120UNSPECIFIED
Ristola, MattiUNSPECIFIEDorcid.org/0000-0001-5115-2811UNSPECIFIED
Faetkenheuer, GerdUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mulcahy, FionaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmid, PatrickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuzovatova, ElenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paduta, DzmitryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Smidt, JelenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Domingo, PereUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Szlavik, JanosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lundgren, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mocroft, AmandaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kirk, OleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-165304
DOI: 10.1097/QAD.0000000000002035
Journal or Publication Title: Aids
Volume: 32
Number: 18
Page Range: S. 2807 - 2820
Date: 2018
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Place of Publication: PHILADELPHIA
ISSN: 1473-5571
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
INJECTING DRUG-USERS; HEPATITIS-C VIRUS; EASTERN-EUROPE; CARE; INFECTION; CASCADE; SEX; CONTINUUM; BARRIERS; RUSSIAMultiple languages
Immunology; Infectious Diseases; VirologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/16530

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