Universität zu Köln

Schatton, Desiree and Rugarli, Elena I. ORCID: 0000-0002-5782-1067 (2018). A concert of RNA-binding proteins coordinates mitochondrial function. Crit. Rev. Biochem. Mol. Biol., 53 (6). S. 652 - 667. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1549-7798

Full text not available from this repository.

Abstract

Mitochondria are dynamic and plastic organelles, which flexibly adapt morphology, ATP production, and metabolic function to meet extrinsic challenges and demands. Regulation of mitochondrial biogenesis is essential during development and in adult life to survive stress and pathological insults, and is achieved not only by increasing mitochondrial mass, but also by remodeling the organellar proteome, metabolome, and lipidome. In the last decade, the post-transcriptional regulation of the expression of nuclear-encoded mitochondrial proteins has emerged as a fast, flexible, and powerful mechanism to shape mitochondrial function and coordinate it with other cellular processes. At the heart of post-transcriptional responses are a number of RNA-binding proteins that specifically bind mRNAs encoding mitochondrial proteins and define their fate, by influencing transcript maturation, stability, translation, and localization. Thus, RNA-binding proteins provide a uniquely complex regulatory code that orchestrates mitochondrial function during physiological and pathological conditions.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schatton, Desiree UNSPECIFIED UNSPECIFIED UNSPECIFIED Rugarli, Elena I. UNSPECIFIED orcid.org/0000-0002-5782-1067 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-166061
DOI:	10.1080/10409238.2018.1553927
Journal or Publication Title:	Crit. Rev. Biochem. Mol. Biol.
Volume:	53
Number:	6
Page Range:	S. 652 - 667
Date:	2018
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1549-7798
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MESSENGER-RNA; POLYADENOSINE RNA; SACCHAROMYCES-CEREVISIAE; GENE-EXPRESSION; PUF FAMILY; RAT-LIVER; P-BODIES; TRANSLATION; LOCALIZATION; YEAST Multiple languages Biochemistry & Molecular Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16606