Universität zu Köln

Voelker, Linus A., Maar, Barbara A., Guevara, Barbara A. Pulido, Bilkei-Gorzo, Andras, Zimmer, Andreas, Broenneke, Hella, Dafinger, Claudia, Bertsch, Sabine, Wagener, Jan-Robin, Schweizer, Heiko, Schermer, Bernhard ORCID: 0000-0002-5194-9000, Benzing, Thomas and Hoehne, Martin (2018). Neph2/Kirrel3 regulates sensory input, motor coordination, and home-cage activity in rodents. Genes Brain Behav., 17 (8). HOBOKEN: WILEY. ISSN 1601-183X

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Abstract

Adhesion molecules of the immunoglobulin superfamily (IgSF) are essential for neuronal synapse development across evolution and control various aspects of synapse formation and maturation. Neph2, also known as Kirrel3, is an IgSF adhesion molecule implicated in synapse formation, synaptic transmission and ultrastructure. In humans, defects in the NEPH2 gene have been associated with neurodevelopmental disorders such as Jacobsen syndrome, intellectual disability, and autism-spectrum disorders. However, the precise role in development and function of the nervous system is still unclear. Here, we present the histomorphological and phenotypical analysis of a constitutive Neph2-knockout mouse line. Knockout mice display defects in auditory sensory processing, motor skills, and hyperactivity in the home-cage analysis. Olfactory, memory and metabolic testing did not differ from controls. Despite the wide-spread expression of Neph2 in various brain areas, no gross anatomic defects could be observed. Neph2 protein could be located at the cerebellar pinceaux. It interacted with the pinceau core component neurofascin and other synaptic proteins thus suggesting a possible role in cerebellar synapse formation and circuit assembly. Our results suggest that Neph2/Kirrel3 acts on the synaptic ultrastructural level and neuronal wiring rather than on ontogenetic events affecting macroscopic structure. Neph2-knockout mice may provide a valuable rodent model for research on autism spectrum diseases and neurodevelopmental disorders.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Voelker, Linus A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Maar, Barbara A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Guevara, Barbara A. Pulido UNSPECIFIED UNSPECIFIED UNSPECIFIED Bilkei-Gorzo, Andras UNSPECIFIED UNSPECIFIED UNSPECIFIED Zimmer, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Broenneke, Hella UNSPECIFIED UNSPECIFIED UNSPECIFIED Dafinger, Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Bertsch, Sabine UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagener, Jan-Robin UNSPECIFIED UNSPECIFIED UNSPECIFIED Schweizer, Heiko UNSPECIFIED UNSPECIFIED UNSPECIFIED Schermer, Bernhard UNSPECIFIED orcid.org/0000-0002-5194-9000 UNSPECIFIED Benzing, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoehne, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-166920
DOI:	10.1111/gbb.12516
Journal or Publication Title:	Genes Brain Behav.
Volume:	17
Number:	8
Date:	2018
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1601-183X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language IMMUNOGLOBULIN SUPERFAMILY; GENE-EXPRESSION; PROTEIN; SYNAPSE; DELETION; PURKINJE; KIRREL3; NEURONS; FAMILY; MOUSE Multiple languages Behavioral Sciences; Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16692