Ruhnke, Markus, Behre, Gerhard, Buchheidt, Dieter, Christopeit, Maximilian ORCID: 0000-0003-4627-0412, Hamprecht, Axel ORCID: 0000-0003-1449-5780, Heinz, Werner ORCID: 0000-0002-7833-9202, Heussel, Claus-Peter, Horger, Marius, Kurzai, Oliver, Karthaus, Meinolf, Loeffler, Juergen, Maschmeyer, Georg, Penack, Olaf, Rieger, Christina, Rickerts, Volker, Ritter, Joerg, Schmidt-Hieber, Martin, Schuelper, Nikolai, Schwartz, Stefan ORCID: 0000-0001-8833-5793, Ullmann, Andrew, Vehreschild, Joerg Janne, von Lilienfeld-Toal, Marie, Weber, Thomas and Wolf, Hans H. (2018). Diagnosis of invasive fungal diseases in haematology and oncology: 2018 update of the recommendations of the infectious diseases working party of the German society for hematology and medical oncology (AGIHO). Mycoses, 61 (11). S. 796 - 814. HOBOKEN: WILEY. ISSN 1439-0507

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Abstract

Invasive fungal diseases (IFD) are a primary cause of morbidity and mortality in patients with haematological malignancies. These infections are mostly life-threatening and an early diagnosis and initiation of appropriate antifungal therapy are essential for the clinical outcome. Most commonly, Aspergillus and Candida species are involved. However, other Non-Aspergillus moulds are increasingly identified in case of documented IFD. For definite diagnosis of IFD, a combination of diagnostic tools have to be applied, including conventional mycological culture and non-conventional microbiological tests such as antibody/antigen and molecular tests, as well as histopathology and radiology. Although varying widely in cancer patients, the risk of invasive fungal infection is highest in those with allogeneic stem cell transplantation and those with acute leukaemia and markedly lower in patients with solid cancer. Since the last edition of Diagnosis of Invasive Fungal Diseases recommendations of the German Society for Hematology and Oncology in 2012, integrated care pathways have been proposed for the management and therapy of IFDs with either a diagnostic driven strategy as opposed to a clinical or empirical driven strategy. This update discusses the impact of this additional evidence and effective revisions.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Ruhnke, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Behre, GerhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buchheidt, DieterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Christopeit, MaximilianUNSPECIFIEDorcid.org/0000-0003-4627-0412UNSPECIFIED
Hamprecht, AxelUNSPECIFIEDorcid.org/0000-0003-1449-5780UNSPECIFIED
Heinz, WernerUNSPECIFIEDorcid.org/0000-0002-7833-9202UNSPECIFIED
Heussel, Claus-PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Horger, MariusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kurzai, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karthaus, MeinolfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Loeffler, JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maschmeyer, GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Penack, OlafUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rieger, ChristinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rickerts, VolkerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ritter, JoergUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt-Hieber, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schuelper, NikolaiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schwartz, StefanUNSPECIFIEDorcid.org/0000-0001-8833-5793UNSPECIFIED
Ullmann, AndrewUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vehreschild, Joerg JanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Lilienfeld-Toal, MarieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weber, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wolf, Hans H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-167199
DOI: 10.1111/myc.12838
Journal or Publication Title: Mycoses
Volume: 61
Number: 11
Page Range: S. 796 - 814
Date: 2018
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1439-0507
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
STEM-CELL TRANSPLANTATION; POLYMERASE-CHAIN-REACTION; BRONCHOALVEOLAR LAVAGE SAMPLES; REAL-TIME PCR; RESOLUTION COMPUTED-TOMOGRAPHY; BONE-MARROW-TRANSPLANTATION; BETA-D-GLUCAN; HIV IMMUNOCOMPROMISED PATIENTS; FEBRILE NEUTROPENIC PATIENTS; RANDOMIZED CONTROLLED-TRIALMultiple languages
Dermatology; MycologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/16719

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