Universität zu Köln

Cerezales, Monica ORCID: 0000-0001-6705-006X, Ocampo-Sosa, Alain A., Alvarez Montes, Laura, Diaz Rios, Catalina, Bustamante, Zulema, Santos, Jazmin, Martinez-Martinez, Luis, Higgins, Paul G. ORCID: 0000-0001-8677-9454 and Gallego, Lucia ORCID: 0000-0003-2885-7789 (2018). High Prevalence of Extensively Drug-resistant Acinetobacter baumannii at a Children Hospital in Bolivia. Pediatr. Infect. Dis. J., 37 (11). S. 1118 - 1124. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1532-0987

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Abstract

Acinetobacter baumannii causes serious hospital-acquired infections and has been positioned as a priority organism by the World Health Organization. This study includes 36 A. baumannii isolates from a children hospital recovered between March 2014 and May 2015 in Cochabamba. The majority of the isolates were recovered from blood cultures (n = 10, 31.3%) and respiratory samples (n = 11, 34.4%); 53% of the patients were younger than 1 month old. Most of these isolates (n = 30, 80.6%) were extremely drug resistant and 8.3% were multidrug resistant. The circulation of 2 predominant clones including 25 isolates was determined by pulsed-field gel electrophoresis; 9 of the isolates were considered sporadic strains. The isolates grouped in the predominant clones and 5 of the unrelated sporadic strains were single-locus variant or double locus variant of clonal complex (CC110), belonging to international clone 7; the rest of the isolates were single-locus variant or double locus variant of another clonal complex. All the carbapenem-resistant isolates (88.9%) carried the bla(OXA-23-like) in a similar structure to Tn2008 located on the chromosome, and the aac(3)-IIa gene was present in all the aminoglycoside-resistant isolates (86.1%). Strong biofilm producers were found among these isolates, being the strongest ones those recovered from the hospital environment, catheter, blood and cerebrospinal fluid (CSF) all of them belonged to the unrelated sporadic strains. The present study demonstrated the predominance and spread of closely related extremely drug-resistant A. baumannii isolates, what confers increasing risk to children and is of major concern because of the kind of infections and the lack of therapeutic alternatives to treat them.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Cerezales, Monica UNSPECIFIED orcid.org/0000-0001-6705-006X UNSPECIFIED Ocampo-Sosa, Alain A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Alvarez Montes, Laura UNSPECIFIED UNSPECIFIED UNSPECIFIED Diaz Rios, Catalina UNSPECIFIED UNSPECIFIED UNSPECIFIED Bustamante, Zulema UNSPECIFIED UNSPECIFIED UNSPECIFIED Santos, Jazmin UNSPECIFIED UNSPECIFIED UNSPECIFIED Martinez-Martinez, Luis UNSPECIFIED UNSPECIFIED UNSPECIFIED Higgins, Paul G. UNSPECIFIED orcid.org/0000-0001-8677-9454 UNSPECIFIED Gallego, Lucia UNSPECIFIED orcid.org/0000-0003-2885-7789 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-167271
DOI:	10.1097/INF.0000000000001962
Journal or Publication Title:	Pediatr. Infect. Dis. J.
Volume:	37
Number:	11
Page Range:	S. 1118 - 1124
Date:	2018
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1532-0987
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HIGH-LEVEL RESISTANCE; AMINOGLYCOSIDE RESISTANCE; OXA CARBAPENEMASES; BIOFILM FORMATION; BETA-LACTAMASE; MULTIPLEX PCR; GENES; ENTEROBACTERIACEAE; EPIDEMIOLOGY; BLA(OXA-23) Multiple languages Immunology; Infectious Diseases; Pediatrics Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16727