Universität zu Köln

Baessler, Bettina ORCID: 0000-0002-3244-3864, Luecke, Christian, Lorz, Julia, Klingel, Karin, von Roeder, Maximilian, de Waha, Suzanne, Besler, Christian, Maintz, David, Gutberlet, Matthias, Thiele, Holger and Lurz, Philipp (2018). Cardiac MRI Texture Analysis of T1 and T2 Maps in Patients with Infarctlike Acute Myocarditis. Radiology, 289 (2). S. 357 - 366. OAK BROOK: RADIOLOGICAL SOC NORTH AMERICA. ISSN 0033-8419

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Abstract

Purpose: To assess the diagnostic potential of texture analysis applied to T1 and T2 maps obtained with cardiac MRI for the diagnosis of acute infarctlike myocarditis. Materials and Methods: This prospective study from August 2012 to May 2015 included 39 participants (overall mean age +/- standard deviation, 34.7 years +/- 12.2 [range, 18-63 years]; mean age of women, 46.1 years +/- 10.8 [range, 24-63 years]; mean age of men, 29.8 years +/- 9.2 [range, 18-56 years]) from the Magnetic Resonance Imaging in Myocarditis (MyoRacer) trial with clinical suspicion of acute myocarditis and infarctlike presentation. Participants underwent biventricular endomyocardial biopsy, cardiac catheterization, and cardiac MRI at 1.5 T, in which native T1 and T2 mapping as well as Lake Louise criteria (LLC) were assessed. Texture analysis was applied on T1 and T2 maps by using a freely available software package. Stepwise dimension reduction and texture feature selection was performed for selecting features enabling the diagnosis of myocarditis by using endomyocardial biopsy as the reference standard. Results: Endomyocardial biopsy confirmed the diagnosis of acute myocarditis in 26 patients, whereas 13 participants had no signs of acute inflammation. Mean T1 and T2 values and LLC showed a low diagnostic performance, with area under the curve in receiver operating curve analyses as follows: 0.65 (95% confidence interval [CI]: 0.45, 0.85) for T1, 0.67 (95% CI: 0.49, 0.85) for T2, and 0.62 (95% CI: 0.42, 0.79) for LLC. Combining the texture features T2 run-length nonuniformity and gray-level nonuniformity resulted in higher diagnostic performance with an area under the curve of 0.88 (95% CI: 0.73, 1.00) (P < .001) and a sensitivity and specificity of 89% [95% CI: 81%, 93%] and 92% [95% CI: 77%, 93%], respectively. Conclusion: Texture analysis of T2 maps shows high sensitivity and specificity for the diagnosis of acute infarctlike myocarditis. (c) RSNA, 2018

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Baessler, Bettina UNSPECIFIED orcid.org/0000-0002-3244-3864 UNSPECIFIED Luecke, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Lorz, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Klingel, Karin UNSPECIFIED UNSPECIFIED UNSPECIFIED von Roeder, Maximilian UNSPECIFIED UNSPECIFIED UNSPECIFIED de Waha, Suzanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Besler, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Maintz, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Gutberlet, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Thiele, Holger UNSPECIFIED UNSPECIFIED UNSPECIFIED Lurz, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-168475
DOI:	10.1148/radiol.2018180411
Journal or Publication Title:	Radiology
Volume:	289
Number:	2
Page Range:	S. 357 - 366
Date:	2018
Publisher:	RADIOLOGICAL SOC NORTH AMERICA
Place of Publication:	OAK BROOK
ISSN:	0033-8419
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MAGNETIC-RESONANCE; TISSUE INHOMOGENEITY; CURRENT STATE; DIAGNOSIS; ACCURACY Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16847