Universität zu Köln

Siedek, Florian, Giese, Daniel, Weiss, Kilian ORCID: 0000-0003-4295-4585, Ekdawi, Sandra, Brinkmann, Sebastian, Schroeder, Wolfgang, Bruns, Christiane, Chang, De-Hua, Persigehl, Thorsten, Maintz, David and Haneder, Stefan (2018). 4D flow MRI for the analysis of celiac trunk and mesenteric artery stenoses. Magn. Reson. Imaging, 53. S. 52 - 63. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1873-5894

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Abstract

Purpose: This study aims to assess the feasibility of 4D flow MRI measurements in complex vascular territories; namely, the celiac artery (CA) and superior mesenteric artery (SMA). Materials and methods: In this prospective study, 22 healthy volunteers and 10 patients were scanned at 3 T. Blood flow parameters were compared between healthy volunteers and patients with stenosis of the CA and/or SMA as a function of stenosis grade characterized by prior contrast-enhanced computed tomography (CE-CT). The 4D flow MRI acquisition covered the CA, SMA and adjusting parts of the abdominal aorta (AO). Measurements of velocity- (peak velocity [PV], average velocity [AV]) and volume-related parameters (peak flow [PF], stroke volume [SV]) were conducted. Further, stenosis grade and wall shear stress in the CA, SMA and AO were evaluated. Results: In patients, prior evaluation by CE-CT revealed 11 low- and 5 mid-grade stenoses of the CA and/or SMA. PV and AV were significantly higher in patients than in healthy volunteers [PV: p < 0.0001; AV: p = 0.03, p < 0.001]. PF and SV did not differ significantly between healthy volunteers and patients; however, a trend towards lower PF and SV could be detected in patients with mid-grade stenoses. Comparison of 4D flow MRI with CE-CT revealed a strong positive correlation in estimated degree of stenosis (CA: r = 0.86, SMA: r = 0.98). Patients with mid-grade stenoses had a significantly higher average WSS magnitude (AWM) than healthy volunteers (p = 0.02). Conclusion: This feasibility study suggests that 4D flow MRI is a viable technique for the evaluation of complex flow characteristics in small vessels such as the CA and SMA. 4D flow MRI approves comparable to the morphologic assessment of complex vascular territories using CE-CT but, in addition, offers the functional evaluation of flow parameters that goes beyond the morphology.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Siedek, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Giese, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Weiss, Kilian UNSPECIFIED orcid.org/0000-0003-4295-4585 UNSPECIFIED Ekdawi, Sandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Brinkmann, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Schroeder, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruns, Christiane UNSPECIFIED UNSPECIFIED UNSPECIFIED Chang, De-Hua UNSPECIFIED UNSPECIFIED UNSPECIFIED Persigehl, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Maintz, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Haneder, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-168794
DOI:	10.1016/j.mri.2018.06.021
Journal or Publication Title:	Magn. Reson. Imaging
Volume:	53
Page Range:	S. 52 - 63
Date:	2018
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1873-5894
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language K-T BLAST; CARDIOVASCULAR MAGNETIC-RESONANCE; BLOOD-FLOW; IN-VIVO; PREOPERATIVE CHEMORADIOTHERAPY; ANASTOMOTIC LEAKAGE; GASTRIC TUBE; AORTIC ROOT; ESOPHAGEAL; HEMODYNAMICS Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16879