Universität zu Köln

Duran, Ibrahim ORCID: 0000-0003-4044-8822, Martakis, K., Rehberg, M., Semler, O. and Schoenau, E. (2018). Individualized evaluation of lumbar bone mineral density and bone mineral apparent density in children and adolescents. Arch. Osteoporos., 13 (1). LONDON: SPRINGER LONDON LTD. ISSN 1862-3514

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Abstract

The SummaryLumbar spine bone mineral density (LS-BMD) assessed by dual-energy X-ray absorptiometry (DXA) is used in children to evaluate bone health. LS-BMD results in children are influenced significantly by height and BMI. An adjustment for these parameters may improve the clinical use of the method.Purpose/IntroductionDXA evaluation is considered useful in children to assess bone health. For this purpose, lumbar spine bone mineral density (LS-BMD) and bone mineral apparent density (LS-BMAD) are often used. The aim of the study was to estimate the effect of height and BMI on LS-BMD and LS-BMAD in children and adolescents and to develop a method to adjust individual results for these factors.MethodsAs part of the National Health and Nutrition Examination Survey (NHANES) study, between the years 2005 and 2010 lumbar DXA scans on randomly selected Americans from 8 to 20years of age were carried out. From all eligible DXA scans, three major US ethnic groups were evaluated (Non-Hispanic Whites, Non-Hispanic Blacks, and Mexican Americans) for further statistical analysis. The relationship between height as well as BMI for age Z-scores and age-adjusted LS-BMD and LS-BMAD Z-scores was analyzed.ResultsFor the statistical analysis, the DXA scans of 1799 non-Hispanic White children (823 females), of 1696 non-Hispanic Black children (817 females), and of 1839 Mexican American children (884 females) were eligible. The statistical analysis showed that taller and heavier children had significantly (p<0.001) higher age-adjusted LS-BMD Z-scores than shorter and lighter children. But on LS-BMAD, only BMI and not height had a significant influence.ConclusionsLS-BMD results in children were influenced significantly by their height and BMI, the LS-BMAD results were only influenced by their BMI. For the first time, the proposed method adjusts LS-BMD and LS-BMAD to BMI. An adjustment of the LS-BMD and LS-BMAD results to these factors might improve the clinical significance of an individual result.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Duran, Ibrahim UNSPECIFIED orcid.org/0000-0003-4044-8822 UNSPECIFIED Martakis, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rehberg, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Semler, O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoenau, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-168941
DOI:	10.1007/s11657-018-0532-7
Journal or Publication Title:	Arch. Osteoporos.
Volume:	13
Number:	1
Date:	2018
Publisher:	SPRINGER LONDON LTD
Place of Publication:	LONDON
ISSN:	1862-3514
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PEDIATRIC OFFICIAL POSITIONS; PUBERTAL DEVELOPMENT; CEREBRAL-PALSY; AGE; MASS; ABSORPTIOMETRY; DENSITOMETRY; CHILDHOOD; MENARCHE; FRACTURE Multiple languages Endocrinology & Metabolism; Orthopedics Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16894