Universität zu Köln

Layher, Evan ORCID: 0000-0001-7215-5077, Santander, Tyler, Volz, Lukas J. ORCID: 0000-0002-0161-654X and Miller, Michael B. (2018). Failure to Affect Decision Criteria During Recognition Memory With Continuous Theta Burst Stimulation. Front. Neurosci., 12. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1662-453X

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Abstract

A decision criterion establishes the minimum amount of memory evidence required for recognition. When a liberal criterion is set, items are recognized based on weak evidence whereas a conservative criterion requires greater memory strength for recognition. The decision criterion is a fundamental aspect of recognition memory but little is known about the underlying neural mechanisms of maintaining a criterion. We used continuous theta burst stimulation (cTBS) with the goal of inhibiting prefrontal cortex excitability while participants performed recognition tests. We hypothesized that inhibiting the right inferior frontal gyrus (rIFG), right middle frontal gyrus (rMFG), and right dorsolateral prefrontal cortex (rDLPFC) would cause participants to establish less conservative decision criteria without affecting recognition memory performance. Participants initially performed recognition memory tests while maintaining conservative decision criteria during fMRI scanning. Peak activity in the successful retrieval effect contrast (Hits > Correct Rejections) provided subject-specific cTBS target sites. During three separate sessions, participants completed the same recognition memory paradigm while maintaining conservative and liberal decision criteria both before and after cTBS. Across two experiments we failed to significantly alter decision criteria placement by applying cTBS to the rIFG, rMFG, and rDLPFC despite efforts to precisely target individualized brain areas. However, we unexpectedly improved discriminability following cTBS to the rDLPFC specifically when participants maintained a liberal criterion. Although this finding may guide future studies investigating the neural mechanisms underlying discriminability in recognition memory, cTBS proved ineffective at altering decision criteria.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Layher, Evan UNSPECIFIED orcid.org/0000-0001-7215-5077 UNSPECIFIED Santander, Tyler UNSPECIFIED UNSPECIFIED UNSPECIFIED Volz, Lukas J. UNSPECIFIED orcid.org/0000-0002-0161-654X UNSPECIFIED Miller, Michael B. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-169402
DOI:	10.3389/fnins.2018.00705
Journal or Publication Title:	Front. Neurosci.
Volume:	12
Date:	2018
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1662-453X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PREFRONTAL CORTEX; RESPONSE BIAS; FRONTAL-LOBE; NEURAL BASIS; ALZHEIMERS-DISEASE; FALSE RECOGNITION; EPISODIC MEMORY; INHIBITION; RECOLLECTION; DISSOCIATION Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16940