Persa, Oana-Diana, Knuever, Jana, Mauch, Cornelia and Schlaak, Max (2018). Complete lymph node dissection or observation in melanoma patients with multiple positive sentinel lymph nodes: A single-center retrospective analysis. J. Dermatol., 45 (10). S. 1191 - 1195. HOBOKEN: WILEY. ISSN 1346-8138

Full text not available from this repository.

Abstract

Although the role of sentinel lymph node biopsy (SLNB) as a prognostic factor is well established, its consequences for therapy are controversial. The aim of this study was to analyze if complete lymph node dissection (CLND) in patients with more than one positive sentinel lymph node (SLN) significantly improves melanoma-specific survival (MSS) and progression-free survival (PFS). Medical records of patients who underwent SLNB between 2001 and 2016 at the University Hospital of Cologne were reviewed, and patients with positive SLN were identified. Patient and tumor characteristics, patterns of recurrence, progression-free and melanoma-specific survival were analyzed. Seventy-eight patients with multiple positive and 197 patients with one positive SLN were included in this study. Patients with multiple positive SLN had significantly more positive non-SLN compared with patients with only one positive SLN (26.9% vs 8.6%, P = 0.01). However, in the subgroup of patients with multiple positive SLN, CLND did not significantly improve MSS (mean MSS 95 vs 75 months, P = 0.5) and PFS (mean PFS 59 vs 68 months P = 0.167). CLND did not result in a significant improvement in PFS and MSS in patients with multiple positive SLN.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Persa, Oana-DianaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Knuever, JanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mauch, CorneliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schlaak, MaxUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-171414
DOI: 10.1111/1346-8138.14577
Journal or Publication Title: J. Dermatol.
Volume: 45
Number: 10
Page Range: S. 1191 - 1195
Date: 2018
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1346-8138
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
STAGE-III; BIOPSY; SURVIVAL; IMPACT; TRIALMultiple languages
DermatologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/17141

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item