Universität zu Köln

Rinschen, Markus M., Limbutara, Kavee, Knepper, Mark A., Payne, D. Michael and Pisitkun, Trairak (2018). FROM MOLECULES TO MECHANISMS: FUNCTIONAL PROTEOMICS AND ITS APPLICATION TO RENAL TUBULE PHYSIOLOGY. Physiol. Rev., 98 (4). S. 2571 - 2607. BETHESDA: AMER PHYSIOLOGICAL SOC. ISSN 1522-1210

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Abstract

Classical physiological studies using electrophysiological, biophysical, biochemical, and molecular techniques have created a detailed picture of molecular transport, bioenergetics, contractility and movement, and growth, as well as the regulation of these processes by external stimuli in cells and organisms. Newer systems biology approaches are beginning to provide deeper and broader understanding of these complex biological processes and their dynamic responses to a variety of environmental cues. In the past decade, advances in mass spectrometry-based proteomic technologies have provided invaluable tools to further elucidate these complex cellular processes, thereby confirming, complementing, and advancing common views of physiology. As one notable example, the application of proteomics to study the regulation of kidney function has yielded novel insights into the chemical and physical processes that tightly control body fluids, electrolytes, and metabolites to provide optimal microenvironments for various cellular and organ functions. Here, we systematically review, summarize, and discuss the most significant key findings from functional proteomic studies in renal epithelial physiology. We also identify further improvements in technological and bioinformatics methods that will be essential to advance precision medicine in nephrology.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rinschen, Markus M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Limbutara, Kavee UNSPECIFIED UNSPECIFIED UNSPECIFIED Knepper, Mark A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Payne, D. Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Pisitkun, Trairak UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-172042
DOI:	10.1152/physrev.00057.2017
Journal or Publication Title:	Physiol. Rev.
Volume:	98
Number:	4
Page Range:	S. 2571 - 2607
Date:	2018
Publisher:	AMER PHYSIOLOGICAL SOC
Place of Publication:	BETHESDA
ISSN:	1522-1210
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MEDULLARY COLLECTING DUCT; THICK ASCENDING LIMB; VASOPRESSIN-STIMULATED INCREASE; PROXIMAL CONVOLUTED TUBULES; LC-MS/MS ANALYSIS; PROTEIN-KINASE-A; MASS-SPECTROMETRY; PHOSPHOPROTEOMIC ANALYSIS; WATER CHANNEL; PHOSPHORYLATION SITES Multiple languages Physiology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17204