Rittweger, Joern, Albracht, Kirsten ORCID: 0000-0002-4271-2511, Flueck, Martin, Ruoss, Severin ORCID: 0000-0001-8896-635X, Brocca, Lorenza, Longa, Emanuela, Moriggi, Manuela, Seynnes, Olivier ORCID: 0000-0002-1289-246X, Di Giulio, Irene ORCID: 0000-0002-4987-6914, Tenori, Leonardo, Vignoli, Alessia, Capri, Miriam ORCID: 0000-0001-9077-0401, Gelfi, Cecilia, Luchinat, Claudio, Francheschi, Claudio, Bottinelli, Roberto, Cerretelli, Paolo and Narici, Marco (2018). Sarcolab pilot study into skeletal muscle's adaptation to long-term spaceflight. NPJ Microgravity, 4. LONDON: SPRINGERNATURE. ISSN 2373-8065

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Abstract

Spaceflight causes muscle wasting. The Sarcolab pilot study investigated two astronauts with regards to plantar flexor muscle size, architecture, and function, and to the underlying molecular adaptations in order to further the understanding of muscular responses to spaceflight and exercise countermeasures. Two crew members (A and B) spent 6 months in space. Crew member A trained less vigorously than B. Postflight, A showed substantial decrements in plantar flexor volume, muscle architecture, in strength and in fiber contractility, which was strongly mitigated in B. The difference between these crew members closely reflected FAK-Y397 abundance, a molecular marker of muscle's loading history. Moreover, crew member A showed downregulation of contractile proteins and enzymes of anaerobic metabolism, as well as of systemic markers of energy and protein metabolism. However, both crew members exhibited decrements in muscular aerobic metabolism and phosphate high energy transfer. We conclude that countermeasures can be effective, particularly when resistive forces are of sufficient magnitude. However, to fully prevent space-related muscular deterioration, intersubject variability must be understood, and intensive exercise countermeasures programs seem mandatory. Finally, proteomic and metabolomic analyses suggest that exercise benefits in space may go beyond mere maintenance of muscle mass, but rather extend to the level of organismic metabolism.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Rittweger, JoernUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Albracht, KirstenUNSPECIFIEDorcid.org/0000-0002-4271-2511UNSPECIFIED
Flueck, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruoss, SeverinUNSPECIFIEDorcid.org/0000-0001-8896-635XUNSPECIFIED
Brocca, LorenzaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Longa, EmanuelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moriggi, ManuelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seynnes, OlivierUNSPECIFIEDorcid.org/0000-0002-1289-246XUNSPECIFIED
Di Giulio, IreneUNSPECIFIEDorcid.org/0000-0002-4987-6914UNSPECIFIED
Tenori, LeonardoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vignoli, AlessiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Capri, MiriamUNSPECIFIEDorcid.org/0000-0001-9077-0401UNSPECIFIED
Gelfi, CeciliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luchinat, ClaudioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Francheschi, ClaudioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bottinelli, RobertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cerretelli, PaoloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Narici, MarcoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-172729
DOI: 10.1038/s41526-018-0052-1
Journal or Publication Title: NPJ Microgravity
Volume: 4
Date: 2018
Publisher: SPRINGERNATURE
Place of Publication: LONDON
ISSN: 2373-8065
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
FOCAL ADHESION KINASE; LOWER-LIMB SUSPENSION; CROSS-SECTIONAL AREA; HUMAN TRICEPS SURAE; BED-REST; PROTEOMIC PROFILE; PROTEIN-SYNTHESIS; OVER-EXPRESSION; ACTIVE RECOVERY; RECEPTOR-ALPHAMultiple languages
Multidisciplinary SciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/17272

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