Randerath, Winfried, Bassetti, Claudio L., Bonsignore, Maria R., Farre, Ramon ORCID: 0000-0002-9084-7824, Ferini-Strambi, Luigi, Grote, Ludger, Hedner, Jan, Kohler, Malcolm, Martinez-Garcia, Miguel-Angel, Mihaicuta, Stefan ORCID: 0000-0001-8897-8342, Montserrat, Josep, Pepin, Jean-Louis, Pevernagie, Dirk, Pizza, Fabio, Polo, Olli, Riha, Renata ORCID: 0000-0001-8983-9985, Ryan, Silke, Verbraecken, Johan and McNicholas, Walter T. (2018). Challenges and perspectives in obstructive sleep apnoea Report by an ad hoc working group of the Sleep Disordered Breathing Group of the European Respiratory Society and the European Sleep Research Society. Eur. Resp. J., 52 (3). SHEFFIELD: EUROPEAN RESPIRATORY SOC JOURNALS LTD. ISSN 1399-3003

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Abstract

Obstructive sleep apnoea (OSA) is a major challenge for physicians and healthcare systems throughout the world. The high prevalence and the impact on daily life of OSA oblige clinicians to offer effective and acceptable treatment options. However, recent evidence has raised questions about the benefits of positive airway pressure therapy in ameliorating comorbidities. An international expert group considered the current state of knowledge based on the most relevant publications in the previous 5 years, discussed the current challenges in the field, and proposed topics for future research on epidemiology, phenotyping, underlying mechanisms, prognostic implications and optimal treatment of patients with OSA. The group concluded that a revision to the diagnostic criteria for OSA is required to include factors that reflect different clinical and pathophysiological phenotypes and relevant comorbidities (e.g. nondipping nocturnal blood pressure). Furthermore, current severity thresholds require revision to reflect factors such as the disparity in the apnoea-hypopnoea index (AHI) between polysomnography and sleep studies that do not include sleep stage measurements, in addition to the poor correlation between AHI and daytime symptoms such as sleepiness. Management decisions should be linked to the underlying phenotype and consider outcomes beyond AHI.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Randerath, WinfriedUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bassetti, Claudio L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bonsignore, Maria R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Farre, RamonUNSPECIFIEDorcid.org/0000-0002-9084-7824UNSPECIFIED
Ferini-Strambi, LuigiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grote, LudgerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hedner, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kohler, MalcolmUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martinez-Garcia, Miguel-AngelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mihaicuta, StefanUNSPECIFIEDorcid.org/0000-0001-8897-8342UNSPECIFIED
Montserrat, JosepUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pepin, Jean-LouisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pevernagie, DirkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pizza, FabioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Polo, OlliUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riha, RenataUNSPECIFIEDorcid.org/0000-0001-8983-9985UNSPECIFIED
Ryan, SilkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Verbraecken, JohanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McNicholas, Walter T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-173599
DOI: 10.1183/13993003.02616-2017
Journal or Publication Title: Eur. Resp. J.
Volume: 52
Number: 3
Date: 2018
Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD
Place of Publication: SHEFFIELD
ISSN: 1399-3003
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
POSITIVE AIRWAY PRESSURE; MANDIBULAR ADVANCEMENT DEVICE; EXCESSIVE DAYTIME SLEEPINESS; QUALITY-OF-LIFE; IDIOPATHIC PULMONARY-FIBROSIS; RANDOMIZED CONTROLLED-TRIAL; FATTY LIVER-DISEASE; NON-CPAP THERAPIES; BLOOD-PRESSURE; GENERAL-POPULATIONMultiple languages
Respiratory SystemMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/17359

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