Universität zu Köln

Parbo, Peter, Ismail, Rola, Sommerauer, Michael, Stokholm, Morten G., Hansen, Allan K., Hansen, Kim V., Amidi, Ali, Schaldemose, Jeppe L., Gottrup, Hanne, Braendgaard, Hans, Eskildsen, Simon F., Borghammer, Per ORCID: 0000-0001-6391-8052, Hinz, Rainer ORCID: 0000-0002-7808-9207, Aanerud, Joel and Brooks, David J. (2018). Does inflammation precede tau aggregation in early Alzheimer's disease? A PET study. Neurobiol. Dis., 117. S. 211 - 217. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1095-953X

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Abstract

Objective: Our aim was to assess with positron emission tomography (PET) the temporal and spatial interrelationships between levels of cortical microglial activation and the aggregated amyloid-beta and tau load in mild cognitive impairment (MCI) and early Alzheimer's disease (AD). Methods: Six clinically probable AD and 20 MCI subjects had inflammation (C-11-(R)-PK11195), amyloid (C-11-PiB) and tau (F-18-flortaucipir) PET, magnetic resonance imaging (MRI) and a neuropsychological assessment. Parametric images of tracer binding were interrogated at a voxel level and by region of interest analyses. Results: 55% of MCI and 83% of AD subjects had a high amyloid-beta load. We have previously reported that clusters of correlated amyloid and inflammation levels are present in cortex. Here we found no correlation between levels of inflammation (C-11-(R)-PK11195 BPND) and tau (F-18-flortaucipir SUVR) or MMSE scores in high amyloid-beta cases. Interpretation: While correlated levels of amyloid-beta and inflammation can be seen in MCI, we did not detect an association between levels of cortical tau tangles and inflammation in our series of high amyloid-P cases. High levels of inflammation could be seen in amyloid-beta positive MCI cases where F-18-flortaucipir signals were low suggesting microglial activation precedes tau tangle formation. Inflammation levels were higher in high amyloid-beta MCI than in early AD cases, compatible with it initially playing a protective role.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Parbo, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Ismail, Rola UNSPECIFIED UNSPECIFIED UNSPECIFIED Sommerauer, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Stokholm, Morten G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hansen, Allan K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hansen, Kim V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Amidi, Ali UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaldemose, Jeppe L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gottrup, Hanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Braendgaard, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED Eskildsen, Simon F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Borghammer, Per UNSPECIFIED orcid.org/0000-0001-6391-8052 UNSPECIFIED Hinz, Rainer UNSPECIFIED orcid.org/0000-0002-7808-9207 UNSPECIFIED Aanerud, Joel UNSPECIFIED UNSPECIFIED UNSPECIFIED Brooks, David J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-173840
DOI:	10.1016/j.nbd.2018.06.004
Journal or Publication Title:	Neurobiol. Dis.
Volume:	117
Page Range:	S. 211 - 217
Date:	2018
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1095-953X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MILD COGNITIVE IMPAIRMENT; AMYLOID-BETA PATHOLOGY; MICROGLIAL ACTIVATION; HUMAN BRAIN; COMPOUND-B; NEUROINFLAMMATION; DEMENTIA; MODEL Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17384