Universität zu Köln

Suchorska, Bogdana, Albert, Nathalie L., Bauer, Elena K., Tonn, Joerg-Christian and Galldiks, Norbert ORCID: 0000-0002-2485-1796 (2018). The role of amino-acid PET in the light of the new WHO classification 2016 for brain tumors. Q. J. Nucl. Med. Mol. Imag., 62 (3). S. 267 - 272. TURIN: EDIZIONI MINERVA MEDICA. ISSN 1827-1936

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Abstract

Since its introduction in 2016, the revision of the World Health Organization (WHO) classification of central nervous system tumors has already changed the diagnostic and therapeutic approach in glial tumors. Blurring the lines between entities formerly labelled as high-grade or low-grade, molecular markers define distinct biological subtypes with different clinical course. This new classification raises the demand for non-invasive imaging methods focusing on depicting metabolic processes. We performed a review of current literature on the use of amino-acid PET (AA-PET) for obtaining diagnostic or prognostic information on glioma in the setting of the current WHO 2016 classification. So far, only a few studies have focused on combining molecular genetic information and metabolic imaging using AA-PET. The current review summarizes the information available on molecular grading as well as prognostic information obtained from AA-PET and delivers an insight into a possible interrelation between metabolic imaging and glioma genetics. Within the framework of molecular characterization of gliomas, metabolic imaging using AA-PET is a promising tool for non-invasive characterization of molecular features and to provide additional prognostic information. Further studies incorporating molecular and metabolic features are necessary to improve the explanatory power of AA-PET in glial tumors.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Suchorska, Bogdana UNSPECIFIED UNSPECIFIED UNSPECIFIED Albert, Nathalie L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bauer, Elena K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tonn, Joerg-Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Galldiks, Norbert UNSPECIFIED orcid.org/0000-0002-2485-1796 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-174529
DOI:	10.23736/S1824-4785.18.03090-X
Journal or Publication Title:	Q. J. Nucl. Med. Mol. Imag.
Volume:	62
Number:	3
Page Range:	S. 267 - 272
Date:	2018
Publisher:	EDIZIONI MINERVA MEDICA
Place of Publication:	TURIN
ISSN:	1827-1936
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DYNAMIC F-18-FET PET; LOW-GRADE GLIOMA; EUROPEAN ASSOCIATION; PROGNOSTIC VALUE; UPTAKE KINETICS; CANCER; IDH; TRANSPORTERS; METABOLISM; MUTATIONS Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17452