Universität zu Köln

Wiesenmueller, Steffi, Cierniak, Peter, Juebner, Martin, Koerner, Enrico, Hegemann, Dirk ORCID: 0000-0003-4226-9326 and Bender, Katja Mercer-Chalmers (2018). Tailored antimicrobial activity and long-term cytocompatibility of plasma polymer silver nanocomposites. J. Biomater. Appl., 33 (3). S. 327 - 340. LONDON: SAGE PUBLICATIONS LTD. ISSN 1530-8022

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Abstract

The deposition of coatings enabling antibacterial properties in combination with cytocompatibility remains a challenge for biomaterial applications, such as in medical devices. Silver is one of the most utilized antibacterial surface components, due to its efficacy and extensive applicability. In this work, silver-containing plasma polymer nanocomposites (single layer and multilayers) were developed and tested, with a focus on cytotoxicity and bactericidal function, on the NIH3T3 mammalian cell line as well as Gram-negative (Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus) bacterial strains. The data demonstrate that a tuneable Ag+ release is required, allowing sufficient antimicrobial activity while retaining appropriate cytocompatibility over the entire testing period of up to eight days.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wiesenmueller, Steffi UNSPECIFIED UNSPECIFIED UNSPECIFIED Cierniak, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Juebner, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Koerner, Enrico UNSPECIFIED UNSPECIFIED UNSPECIFIED Hegemann, Dirk UNSPECIFIED orcid.org/0000-0003-4226-9326 UNSPECIFIED Bender, Katja Mercer-Chalmers UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-174582
DOI:	10.1177/0885328218793488
Journal or Publication Title:	J. Biomater. Appl.
Volume:	33
Number:	3
Page Range:	S. 327 - 340
Date:	2018
Publisher:	SAGE PUBLICATIONS LTD
Place of Publication:	LONDON
ISSN:	1530-8022
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANTIBACTERIAL ACTIVITY; IN-VITRO; STAPHYLOCOCCUS-AUREUS; IMPLANT INFECTIONS; OXIDATIVE STRESS; BURST-RELEASE; NANOPARTICLES; FILMS; CYTOTOXICITY; MULTILAYER Multiple languages Engineering, Biomedical; Materials Science, Biomaterials Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17458