Universität zu Köln

Boesch, Florian, Hofmann, Katharina, Coenen, Michaela ORCID: 0000-0001-7492-7907, Pratschke, Sebastian, Thomas, Michael, Knoesel, Thomas, Bruns, Christiane J., Guba, Markus, Werner, Jens and Angele, Martin K. (2018). Surgical treatment of pNET - Experience of a high-volume center. Surg. Oncol.-Oxf., 27 (3). S. 409 - 415. OXFORD: ELSEVIER SCI LTD. ISSN 1879-3320

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Abstract

Background: Neuroendocrine tumors of the pancreas (pNETs) are a rare disease. Grading according to the Ki67-index is the most validated risk factor. Nevertheless, controversies exist concerning other prognostic factors. The aim of this study was to evaluate published risk factors. Methods: Patients with pancreatic NETs who underwent surgery at our department from 2000 to 2014 were analyzed. The patient and tumor characteristics were evaluated. Kaplan-Meier analyses, univariate calculations as well as multivariate analyses were performed. Results: In total, 98 patients underwent surgery due to a pNET. The final study population consisted of 88 patients. Univariate analysis demonstrated that overall survival is influenced by tumor grading, local resection margin and presence of distant metastases. However, in the multivariate analysis, only grading and the resection margin had prognostic significance. The size of the primary tumor directly correlated with the probability of metastases. Multivisceral operations had no influence on morbidity or mortality. Conclusions: Resection of pNETs is the only curative treatment and is safe. Since the incidence of pNETs is low, treatment should be performed at a high-volume center.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Boesch, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Hofmann, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Coenen, Michaela UNSPECIFIED orcid.org/0000-0001-7492-7907 UNSPECIFIED Pratschke, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Thomas, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Knoesel, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruns, Christiane J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Guba, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Werner, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Angele, Martin K. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-174655
DOI:	10.1016/j.suronc.2018.05.027
Journal or Publication Title:	Surg. Oncol.-Oxf.
Volume:	27
Number:	3
Page Range:	S. 409 - 415
Date:	2018
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	1879-3320
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PANCREATIC NEUROENDOCRINE TUMORS; LONG-TERM SURVIVAL; ENETS CONSENSUS GUIDELINES; ENDOCRINE TUMORS; MANAGEMENT; RESECTION; METASTASES; NEOPLASMS; SURGERY; LIVER Multiple languages Oncology; Surgery Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17465