Universität zu Köln

Mikosinski, Jacek, Kotala, Marek, Stuecker, Markus, Twardowska-Saucha, Krystyna, Bonnekoh, Bernd, Panczak, Konrad, Aleksiejew-Kleszczynski, Tomasz, Dissemond, Joachim, Eming, Sabine A., Kaspar, Daniela, Rousseau, Anne, Bewert, Johanna, Schroeder, Wiebke and Smola, Hans (2018). Clinical assessment of a foam dressing containing growth factor-enhancing hydrated polyurethanes. J. Wound Care, 27 (9). S. 608 - 618. LONDON: MA HEALTHCARE LTD. ISSN 2062-2916

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Abstract

Objective: This study assesses a novel dressing concept in venous leg ulcer (VLU) patients. It is based on boosting endogenous growth factor activities synthesised by functional granulation tissue. Methods: Patients received treatment for eight weeks with a hydrated polyurethane-containing foam dressing plus concomitant compression therapy. Wound area reduction (WAR), percentage of wounds achieving a relative WAR of >= 40% and >= 60%, wound pain ratings for the last 24 hours and at dressing changes, EQ-5D Quality of Life questionnaire data, dressing handling and safety parameters were recorded. Results: There were 128 patients who received treatment and data for 123 wound treatment courses were documented. Wound area size decreased from 13.3 +/- 9.8cm(2) to 10.5 +/- 12.2cm(2) at week eight and median relative WAR was 48.8%. At week eight, a relative WAR >= 40% was reached by 54.5% of the wounds, 41.5% reached a relative WAR of >= 60% and complete healing was observed in 13.5% of wounds. Median wound pain ratings (last 24 hours before dressing change) declined significantly from 30 to 15.5 (100 visual analogue scale [VAS), p=0.0001) and pain at dressing changes from 30 to 12.5 (1)5.0.0001). The EQ-5D VAS rating increased from 58.4 +/- 19.2mm to 63.1 +/- 19.1mm (p=0.0059). Conclusion: This clinical assessment shows that the concept of boosting endogenous growth factors through hydrated polyurethanes has the potential to accelerate WAR in VLU patients while decreasing pain levels and improving quality of life parameters.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mikosinski, Jacek UNSPECIFIED UNSPECIFIED UNSPECIFIED Kotala, Marek UNSPECIFIED UNSPECIFIED UNSPECIFIED Stuecker, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Twardowska-Saucha, Krystyna UNSPECIFIED UNSPECIFIED UNSPECIFIED Bonnekoh, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Panczak, Konrad UNSPECIFIED UNSPECIFIED UNSPECIFIED Aleksiejew-Kleszczynski, Tomasz UNSPECIFIED UNSPECIFIED UNSPECIFIED Dissemond, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Eming, Sabine A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaspar, Daniela UNSPECIFIED UNSPECIFIED UNSPECIFIED Rousseau, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Bewert, Johanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Schroeder, Wiebke UNSPECIFIED UNSPECIFIED UNSPECIFIED Smola, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-174740
DOI:	10.12968/jowc.2018.27.9.608
Journal or Publication Title:	J. Wound Care
Volume:	27
Number:	9
Page Range:	S. 608 - 618
Date:	2018
Publisher:	MA HEALTHCARE LTD
Place of Publication:	LONDON
ISSN:	2062-2916
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VENOUS LEG ULCERS; CHRONIC WOUNDS; LOCAL-MANAGEMENT; EPIDEMIOLOGY; PREDICTORS; MATRIX; REPAIR; FLUID; AREA Multiple languages Dermatology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17474