Universität zu Köln

Rempel, V, Safi, A. F., Drebber, U., Nickenig, H. J., Neugebauer, J., Zoeller, J. E. and Kreppel, M. (2018). The prognostic relevance of lymph node ratio in patients with oral squamous cell carcinoma treated with neoadjuvant therapy regimen and radical surgery. J. Cranio-MaxilloFac. Surg., 46 (9). S. 1659 - 1664. EDINBURGH: CHURCHILL LIVINGSTONE. ISSN 1878-4119

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Abstract

Background: This study aims at investigating the prognostic significance of lymph node ratio (LNR) in a cohort of patients with oral squamous cell carcinomas (OSCC), treated with neoadjuvant radio-chemotherapy followed by radical surgery. Methods: The study included 171 treatment-naive patients with biopsy-proven primary OSCC, being reviewed retrospectively. All patients received a concomitant neoadjuvant radiochemotherapy (RCT) followed by radical surgery of the primary tumor and neck dissection based on the pretreatment staging results. The Kaplan-Meier survival analysis method was used to estimate the events of interest for overall survival (OS). Prognostic factors were identified through univariate and multivariate analysis. Results: The 5-year overall survival rate for all patients was 48 %. In univariate analysis, patient's age and data compiled from the histopathological examination as margin status, extracapsular spread, ypT, ypN, ypUICC, number of positive lymph nodes and lymph node ratio (LNR) had a statistically significant impact on overall survival. Multivariate analysis revealed an independent significant impact of patient age, ypT, margin status and LNR on OS. ypN showed no statistical significant impact on OS. Conclusion: Our results show that LNR is an important predictor for OS in patients with OSCC that were treated with neoadjuvant radiochemotherapy and radical surgery. (C) 2018 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rempel, V UNSPECIFIED UNSPECIFIED UNSPECIFIED Safi, A. F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Drebber, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nickenig, H. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Neugebauer, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zoeller, J. E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreppel, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-175159
DOI:	10.1016/j.jcms.2018.05.053
Journal or Publication Title:	J. Cranio-MaxilloFac. Surg.
Volume:	46
Number:	9
Page Range:	S. 1659 - 1664
Date:	2018
Publisher:	CHURCHILL LIVINGSTONE
Place of Publication:	EDINBURGH
ISSN:	1878-4119
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NECK-CANCER; CAVITY CANCER; LOCOREGIONAL RECURRENCE; RETROSPECTIVE ANALYSIS; OROPHARYNGEAL CANCER; ADJUVANT THERAPY; RECTAL-CANCER; HEAD; SURVIVAL; RADIOCHEMOTHERAPY Multiple languages Dentistry, Oral Surgery & Medicine; Surgery Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17515