Bschor, T., Henssler, J., Mueller, M. and Baethge, C. (2018). Baclofen for alcohol use disordera systematic meta-analysis. Acta Psychiatr. Scand., 138 (3). S. 232 - 243. HOBOKEN: WILEY. ISSN 1600-0447
Full text not available from this repository.Abstract
ObjectiveTo evaluate the efficacy and tolerability of baclofen vs. placebo for long-term treatment of alcohol use disorder. MethodSystematic review and meta-analysis following methods of the Cochrane Collaboration Handbook (PROSPERO registration: CRD42017073663). Primary outcome was the random-effects summary estimate of all standardized mean differences (SMDs), as calculated from the primary outcomes of each study. ResultsFourteen double-blind RCTs (1522 patients) were included. Heterogeneity was substantial for most analyses (I-2 about 75%). Baclofen showed a small, but not statistically significant superiority over placebo: SMD=0.22 ([95% CI: -0.03; 0.47], P=0.09). This result was supported by a leave-one-out-analysis, and Orwin's fail-safe N, by predefined secondary analyses (on abstinence rates and amount of drinking), and by a post hoc-analysis of high-dose studies (>80mg/day). An analysis of low risk of bias studies (SMD=0.10 [-0.20; 0.41], P=0.51, I-2=43.3%) found no effect. Exclusion of four studies focusing on patients with comorbidity yielded a small positive effect. Drop-out rates were similar. ConclusionOur results question baclofen's utility in the long-term treatment of alcohol use disorder at both normal and high doses. While the confidence intervals indicate that marginally harmful or moderately beneficial effects of baclofen remain a possibility, the most likely effect size is slightly above placebo effects.
Item Type: | Journal Article | ||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-175604 | ||||||||||||||||||||
DOI: | 10.1111/acps.12905 | ||||||||||||||||||||
Journal or Publication Title: | Acta Psychiatr. Scand. | ||||||||||||||||||||
Volume: | 138 | ||||||||||||||||||||
Number: | 3 | ||||||||||||||||||||
Page Range: | S. 232 - 243 | ||||||||||||||||||||
Date: | 2018 | ||||||||||||||||||||
Publisher: | WILEY | ||||||||||||||||||||
Place of Publication: | HOBOKEN | ||||||||||||||||||||
ISSN: | 1600-0447 | ||||||||||||||||||||
Language: | English | ||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||
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Refereed: | Yes | ||||||||||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/17560 |
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