Halbach, Marcel, Abraham, William T., Butter, Christian, Ducharme, Anique ORCID: 0000-0003-1681-9187, Klug, Didier, Little, William C., Reuter, Hannes, Schafer, Jill E., Senni, Michele, Swarup, Vijay, Wachter, Rolf ORCID: 0000-0003-2231-2200, Weaver, Fred A., Wilks, Seth J., Zile, Michael R. and Mueller-Ehmsen, Jochen (2018). Baroreflex activation therapy for the treatment of heart failure with reduced ejection fraction in patients with and without coronary artery disease. Int. J. Cardiol., 266. S. 187 - 193. CLARE: ELSEVIER IRELAND LTD. ISSN 1874-1754

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Abstract

Background: In a randomized trial, baroreflex activation therapy (BAT) improved exercise capacity, quality of life and NT-proBNP in patients with heart failure with reduced ejection fraction (HFrEF). In view of different mechanisms underlying HFrEF, we performed a post-hoc subgroup analysis of efficacy and safety of BAT in patients with and without coronary artery disease (CAD). Methods and results: Patients with left ventricular ejection fraction <35% and NYHA Class III were randomized 1:1 to guideline-directedmedical and device therapy alone or plus BAT. Patients with a history of CAD, priormyocardial infarction or coronary artery bypass graft were assigned to the CAD group with all others assigned to the no-CAD group. Of 71 BAT treated patients, 52 had CAD and 19 had no CAD. In the control group, 49 of 69 patients had CAD and 20 had no CAD. The system-or procedure-related major adverse neurological or cardiovascular event rate was 3.8% in the CAD group vs. 0% in the no-CAD group (p = 1.0). In the whole cohort, NYHA Class, Minnesota Living with Heart Failure score, 6-minute hall walk distance and NTproBNP were improved in BAT treated patients compared with controls. Statistical analyses revealed no interaction between the presence of CAD and effect of BAT (all p > 0.05). Conclusion: No major differences were found in BAT efficacy or safety between patients with and without CAD, indicating that BAT improves exercise capacity, quality of life and NTproBNP in patients with ischemic and non-ischemic cardiomyopathy. (C) 2018 Elsevier B.V. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Halbach, MarcelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Abraham, William T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Butter, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ducharme, AniqueUNSPECIFIEDorcid.org/0000-0003-1681-9187UNSPECIFIED
Klug, DidierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Little, William C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reuter, HannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schafer, Jill E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Senni, MicheleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Swarup, VijayUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wachter, RolfUNSPECIFIEDorcid.org/0000-0003-2231-2200UNSPECIFIED
Weaver, Fred A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wilks, Seth J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zile, Michael R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller-Ehmsen, JochenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-175897
DOI: 10.1016/j.ijcard.2018.04.075
Journal or Publication Title: Int. J. Cardiol.
Volume: 266
Page Range: S. 187 - 193
Date: 2018
Publisher: ELSEVIER IRELAND LTD
Place of Publication: CLARE
ISSN: 1874-1754
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CARDIAC RESYNCHRONIZATION; ISCHEMIC CARDIOMYOPATHY; BLOOD-PRESSURE; SAFETY; ETIOLOGY; EFFICACYMultiple languages
Cardiac & Cardiovascular SystemsMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/17589

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