Universität zu Köln

Hoser, Dana, Schoen, Christian, Loddenkemper, Christoph, Lohneis, Philipp, Kuehl, Anja A., Sommermann, Thomas, Blankenstein, Thomas and Willimsky, Gerald (2018). Oncogene-specific T cells fail to eradicate lymphoma-initiating B cells in mice. Blood, 132 (9). S. 924 - 935. WASHINGTON: AMER SOC HEMATOLOGY. ISSN 1528-0020

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Abstract

To date, little is known about the interaction between (pre-)malignant B cells and T cells. We generated transgenic mice that allow B cell-specific induction of the oncogene SV40 large T-antigen (TAg) to analyze the role of oncogene-specific T cells during sporadic B-cell lymphoma development. Constitutive TAg expression in CD19-Cre x LoxP-Tag mice resulted in TAg-tolerant CD8(+) T cells and development of B-cell lymphomas. In contrast, CD19-CreER(T2) x LoxP-Tag mice retained TAg-competent CD8(+) T cells at time of oncogene induction and TAg expression in few B cells of adult mice resulted in exceptionally rare lymphoma formation late in life. Increased lymphoma incidence in the absence of TAg-specific T cells suggested T cell-mediated inhibition of lymphoma progression. However, TAg-initiated B cells were not eliminated by T cells and detected long term. Our results demonstrate a failure of the immune system to eradicate lymphoma-initiating B cells, retaining the risk of lymphoma development.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hoser, Dana UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoen, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Loddenkemper, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Lohneis, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuehl, Anja A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sommermann, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Blankenstein, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Willimsky, Gerald UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-175950
DOI:	10.1182/blood-2018-02-834036
Journal or Publication Title:	Blood
Volume:	132
Number:	9
Page Range:	S. 924 - 935
Date:	2018
Publisher:	AMER SOC HEMATOLOGY
Place of Publication:	WASHINGTON
ISSN:	1528-0020
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EPSTEIN-BARR-VIRUS; ANTIGEN-PRESENTING CELLS; MOUSE MODEL; TOLERANCE INDUCTION; IMMUNE SURVEILLANCE; IN-VIVO; TRANSGENIC MICE; C57BL/6 MICE; PROTEIN; CD4(+) Multiple languages Hematology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17595